Mechanics of Rouleau formation.

Biophysical journal ·Vol. 35 ·No. 3 ·1981-09-00 ·Pages 771-81

Skalak R, Zarda PR, Jan KM, Chien S

Abstract

The formation of rouleau of red blood cells is considered from the standpoint of adhesion theory. With the use of the elastic properties of the red blood cell membrane obtained from previous work, the strain energy of the red blood cell in rouleau formation has been computed. The surface energy of adhesion for the bonding of two red blood cells is then computed from the variation of this strain energy. Computed cell shapes agree well with experiments.

MeSH Terms

Cell Adhesion Erythrocyte Membrane/ultrastructure Erythrocytes/physiology,ultrastructure Humans Mathematics Microscopy, Electron Models, Biological Surface Properties

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Skalak R

Zarda P R

Jan K M

Chien S

References (8)

8 references, click to expand

Improved measurements of the erythrocyte geometry.
Microvasc Res. 1972 Oct;4(4):335-47 PMID: 4635577
Ultrastructural basis of the mechanism of rouleaux formation.
Microvasc Res. 1973 Mar;5(2):155-66 PMID: 4694282
Strain energy function of red blood cell membranes.
Biophys J. 1973 Mar;13(3):245-64 PMID: 4697236
Role of surface electric charge in red blood cell interactions.
J Gen Physiol. 1973 May;61(5):638-54 PMID: 4705641
Influence of the ionic composition of fluid medium on red cell aggregation.
J Gen Physiol. 1973 May;61(5):655-68 PMID: 4705642
Electrochemical interactions between erythrocyte surfaces.
Thromb Res. 1976 May;8(2 suppl):189-202 PMID: 936075
Elastic deformations of red blood cells.
J Biomech. 1977;10(4):211-21 PMID: 858727
Minimum energy analysis of membrane deformation applied to pipet aspiration and surface adhesion of red blood cells.
Biophys J. 1980 May;30(2):265-84 PMID: 7260275

Article Info

Journal

Biophysical journal

Abbr.

Biophys J

ISSN

0006-3495

DOI

10.1016/S0006-3495(81)84826-6

Published

1981-09-00

Pages

771-81

Language

English

Region

United States

NLM ID

0370626

PMCID

PMC1327562

Subset

External Links

PubMed source DOI: 10.1016/S0006-3495(81)84826-6 PMC Full Text View journal details

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