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PMID: 7263072 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Rejection of the intestinal parasite Nippostrongylus brasiliensis by mast cell-deficient W/Wv anemic mice.

Infection and immunity ·Vol. 33 ·No. 1 ·1981-07-00 ·Pages 54-8

Crowle PK, Reed ND

Abstract

The ability of W/Wv anemic mice to accumulate mucosal mast cells and to reject the intestinal parasite Nippostrongylus brasiliensis was examined. W/Wv mice did not accumulate mucosal mast cells in response to infections with N. brasiliensis. They eliminated a primary infection more slowly than did their normal littermate controls but were as refractory as controls to second and third infections. W/Wv mice had higher serum titers of worm-specific immunoglobulin E than did controls. These results indicate that mucosal mast cells are not an absolute requirement for N. brasiliensis rejection.

MeSH Terms
Animals Immunoglobulin E/analysis Intestinal Mucosa/pathology Intestines/parasitology Mast Cells/physiology Mice Mice, Inbred BALB C Mice, Nude Nematode Infections/immunology,parasitology Nippostrongylus/growth & development Parasite Egg Count
Chemicals
Immunoglobulin E
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crowle P K
Reed N D
References (31)
31 references, click to expand
  1. Relationship of globule leucocytes to gastrointestinal nematodes in the sheep, and Nippostrongylus brasiliensis and Hymenolepis nana infections in rats.
    J Comp Pathol. 1966 Jan;76(1):57-65 PMID: 5948537
  2. The copper phthalocyanin dye "Astrablau" and its staining properties, especially the staining of mast cells.
    Z Zellforch Microsk Anat Histochem. 1960;2:48-57 PMID: 13801612
  3. The immune response in mice of genotypes W-Wv and Sl-Sld1.
    Proc Soc Exp Biol Med. 1969 Oct;132(1):115-9 PMID: 5344823
  4. Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat.
    Immunology. 1971 Mar;20(3):277-88 PMID: 5551353
  5. Mast cells and macromolecular leak in intestinal immunological reactions. The influence of sex of rats infected with Nippostrongylus brasiliensis.
    Immunology. 1971 Jul;21(1):17-31 PMID: 5105046
  6. Communications. Heterologous adoptive cutaneous anaphylaxis: a method for detecting reaginic antibody formation by cells of the mouse.
    J Immunol. 1973 Aug;111(2):638-40 PMID: 4736939
  7. Reaginic antibodies and helminth infection.
    Vet Rec. 1973 Nov 3;93(18):480-3 PMID: 4206703
  8. Co-operation between antibodies and cells in immunity to a nematode parasite.
    Transplant Rev. 1974;19(0):147-69 PMID: 4601808
  9. The immune response of congenitally athymic (nude) mice to the intestinal nematode Nippostrongylus brasiliensis.
    Proc Soc Exp Biol Med. 1974 Dec;147(3):667-70 PMID: 4614268
  10. PCA reactions with mouse antibodies in mice and rats.
    Int Arch Allergy Appl Immunol. 1975;48(1):16-21 PMID: 1116878
  11. Thymus dependence of tapeworm (Hymenolepis diminuta) elimination from mice.
    Infect Immun. 1975 Dec;12(6):1478-9 PMID: 1205624
  12. Development of rat mast cells in vitro. I. Differentiation of mast cells from thymus cells.
    J Immunol. 1976 Mar;116(3):747-54 PMID: 1254953
  13. Mast cells in the skin of normal, hairless and athymic mice.
    Experientia. 1976 Feb 15;32(2):171-2 PMID: 817924
  14. Absence of intestinal mast cell response in congenitally athymic mice during Trichinella spiralis infection.
    Nature. 1976 Nov 18;264(5583):258-60 PMID: 1087373
  15. Mast cells in the pinna of Balb/c 'nude' (nu/nu) and heterozygotes (ny/+)mice.
    Experientia. 1976 Dec 15;32(12):1591-2 PMID: 1021461
  16. Theta-sensitive cell and erythropoiesis: identification of a defect in W/Wv anemic mice.
    Science. 1977 Apr 15;196(4287):313-5 PMID: 322288
  17. The probable relationship of some or all mast cells to the T-cell system.
    Cell Immunol. 1977 May;30(2):358-60 PMID: 67911
  18. Thymus dependence and independence of intestinal pathology in a Trichinella spiralis infection: a study in congenitally athymic (nude) mice.
    Br J Exp Pathol. 1977 Jun;58(3):311-4 PMID: 871379
  19. Expulsion of Nippostrongylus brasiliensis from mice lacking antibody production potential.
    Immunology. 1977 Jun;32(6):867-74 PMID: 328383
  20. Development of mast cells from grafted bone marrow cells in irradiated mice.
    Nature. 1977 Aug 4;268(5619):442-3 PMID: 331117
  21. The course of Hymenolepis nana infections in thymus-deficient mice.
    Int Arch Allergy Appl Immunol. 1977;55(1-6):504-13 PMID: 338509
  22. Immune inflammatory responses to parasites: the role of basophils, mast cells and vasoactive amines.
    Am J Trop Med Hyg. 1977 Nov;26(6 Pt 2):96-103 PMID: 74213
  23. Hymenolepis diminuta infections in congenitally athymic (nude) mice: worm kinetics and intestinal histopathology.
    Immunology. 1978 Jan;34(1):105-13 PMID: 624564
  24. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation.
    Blood. 1978 Aug;52(2):447-52 PMID: 352443
  25. Small intestinal cryptogenic cells in W/Wv mutant mice.
    Radiat Res. 1978 Apr;74(1):139-43 PMID: 674561
  26. Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice.
    Blood. 1978 Oct;52(4):802-17 PMID: 28803
  27. The mast cell--a fascinating riddle.
    N Engl J Med. 1979 Aug 30;301(9):498-9 PMID: 460369
  28. Distribution of mast-cell precursors in hematopoeitic and lymphopoietic tissues of mice.
    J Exp Med. 1979 Sep 19;150(3):482-90 PMID: 383876
  29. Expulsion of Nippostrongylus brasiliensis by mice deficient in mast cells.
    Nature. 1980 Sep 18;287(5779):226-8 PMID: 7432459
  30. FORMATION OF PURE SUSPENSIONS OF MAST CELLS IN TISSUE CULTURE BY DIFFERENTIATION OF LYMPHOID CELLS FROM THE MOUSE THYMUS.
    J Natl Cancer Inst. 1963 Jul;31:1-39 PMID: 14043037
  31. Mast cells in rat gastrointestinal mucosa. I. Effects of fixation.
    Acta Pathol Microbiol Scand. 1966;66(3):289-302 PMID: 4162017
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.33.1.54-58.1981
Published
1981-07-00
Pages
54-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC350652
Subset
IM
Grants
NCI NIH HHS · CA-24443 · United States
NCRR NIH HHS · RR-09135 · United States
External Links
PubMed source DOI: 10.1128/iai.33.1.54-58.1981 PMC Full Text View journal details
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