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PMID: 7259913 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of acute and chronic beta-receptor blockade on ventricular repolarisation in man.

British heart journal ·Vol. 45 ·No. 6 ·1981-06-00 ·Pages 628-36

Edvardsson N, Olsson SB

Abstract

The right ventricular repolarisation phase was studied electrophysiologically after an injection of 15 mg metoprolol in 16 healthy volunteers. Eight of them were restudied after chronic treatment with 400 mg metoprolol daily for five weeks. The assessment of the repolarisation time included ventricular effective refractory periods, monophasic action potential duration, and the QT interval measured during atrial stimulation at different driving frequencies. The acute administration of 15 mg metoprolol intravenously had no detectable effect on the repolarisation phase, while chronic treatment caused a significant increase of the ventricular effective refractory periods, monophasic action potential duration, and the QT interval during atrial stimulation. Thus the study confirmed the contrasting effect of acute and chronic beta-receptor blockade on the ventricular repolarisation time in man.

MeSH Terms
Action Potentials/drug effects Adult Drug Administration Schedule Electrocardiography Heart Conduction System/drug effects Heart Rate/drug effects Heart Ventricles/drug effects Humans Male Metoprolol/administration & dosage,blood,pharmacology Propanolamines/pharmacology Ventricular Function
Chemicals
Propanolamines Metoprolol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Edvardsson N
Olsson S B
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19 references, click to expand
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Article Info
Journal
British heart journal
Abbr.
Br Heart J
ISSN
0007-0769
DOI
10.1136/hrt.45.6.628
Published
1981-06-00
Pages
628-36
Language
English
Region
England
NLM ID
0370634
PMCID
PMC482575
Subset
IM
External Links
PubMed source DOI: 10.1136/hrt.45.6.628 PMC Full Text View journal details
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