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PMID: 7236212 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Human atrial and ventricular myosin light-chains subunits in the adult and during development.

The Biochemical journal ·Vol. 191 ·No. 2 ·1980-11-01 ·Pages 571-80

Price KM, Littler WA, Cummins P

Abstract

1. Myosin was isolated from human right- and left-atrial and -ventricular myocardium, and examined both in adult subjects and at different stages during pre- and post-natal development. 2. The myosin light-chain subunits in the atria and ventricles were different when characterized by isoelectric focusing and subsequent two-dimensional poly-acrylamide-gel electrophoresis. 3. No differences were observed between the light-chain subunits in the right and left ventricle at any stage of development. 4. The foetal ventricle contained a characteristic light chain that was a major component throughout the latter half of gestation. This foetal light chain, which disappeared in the postnatal period, could not be distinguished from adult atrial light chain 1 on two-dimensional electrophoresis. 5. Myosin in the adult atria, particularly the left, contained components similar to ventricular light-chain components. 6. The possible stimuli for the observed changes in myosin light-chain expression are discussed in relation to the known physiological changes occurring during development.

MeSH Terms
Adult Aged Electrophoresis, Polyacrylamide Gel Female Fetal Heart/metabolism Heart/growth & development Heart Atria/metabolism Heart Ventricles/metabolism Humans Infant Infant, Newborn Isoelectric Focusing Male Middle Aged Myocardium/metabolism Myosins/metabolism
Chemicals
Myosins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Price K M
Littler W A
Cummins P
References (39)
39 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1910571
Published
1980-11-01
Pages
571-80
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1162249
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1910571 PMC Full Text View journal details
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