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PMID: 7204562 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.

The Journal of clinical investigation ·Vol. 67 ·No. 3 ·1981-03-00 ·Pages 903-6

McManus LM, Hanahan DJ, Pinckard RN

Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

MeSH Terms
Blood Coagulation Factors/metabolism Blood Platelets/drug effects Dose-Response Relationship, Drug Humans Lysophosphatidylcholines/pharmacology Platelet Activating Factor Platelet Aggregation/drug effects Platelet Factor 4/metabolism Serotonin/metabolism Time Factors
Chemicals
Blood Coagulation Factors Lysophosphatidylcholines Platelet Activating Factor Serotonin Platelet Factor 4
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
McManus L M
Hanahan D J
Pinckard R N
References (22)
22 references, click to expand
  1. Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen.
    J Exp Med. 1970 Feb;131(2):287-306 PMID: 5419850
  2. Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.
    Nature. 1974 Jun 7;249(457):581-2 PMID: 4275800
  3. The release of four mediators of immediate hypersensitivity from human leukemic basophils.
    J Immunol. 1975 Jan;114(1 Pt 1):87-92 PMID: 46247
  4. Letter: Aggregation of human platelets by platelet-activating factor.
    Lancet. 1975 Feb 8;1(7902):344-5 PMID: 46496
  5. Mediator release from basophil granulocytes in chronic myelogenous leukemia.
    J Allergy Clin Immunol. 1976 Dec;58(6):623-34 PMID: 62774
  6. Platelet activating factor (PAF). A possible direct mediator of anaphylaxis in the rabbit and a trigger for the vascular deposition of circulating immune complexes.
    Monogr Allergy. 1977;12:13-26 PMID: 335211
  7. Platelet-activating factor.
    Monogr Allergy. 1977;12:138-42 PMID: 335212
  8. Development of a radioimmunoassay for human platelet factor 4.
    Thromb Res. 1977 Nov;11(5):673-86 PMID: 412272
  9. Activation of human platelets by platelet activating factor (PAF) derived from sensitized rabbit basophils.
    Immunology. 1978 Dec;35(6):953-8 PMID: 738767
  10. The release of a platelet-activating factor by stimulated rabbit neutrophils.
    J Immunol. 1979 Sep;123(3):1219-26 PMID: 469247
  11. [Liberation of platelet activating factor (P.A.F.) by alveolar macrophages].
    Nouv Presse Med. 1979 Jun 7;8(25):2071-2 PMID: 382102
  12. Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.
    J Immunol. 1979 Oct;123(4):1847-57 PMID: 479602
  13. Platelet-activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes.
    Eur J Immunol. 1979 May;9(5):409-15 PMID: 385330
  14. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).
    J Biol Chem. 1979 Oct 10;254(19):9355-8 PMID: 489536
  15. The immunological generation of a platelet-activating factor and a platet-lytic factor in the rat.
    Immunology. 1979 Aug;37(4):841-8 PMID: 227784
  16. Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro and during IgE anaphylaxis in the rabbit.
    J Immunol. 1979 Dec;123(6):2835-41 PMID: 501092
  17. Release of platelet-activating factor by peritoneal and alveolar macrophages.
    Monogr Allergy. 1979;14:138-41 PMID: 388195
  18. Human neutrophil-derived platelet activating factor.
    J Immunol. 1980 Feb;124(2):676-84 PMID: 7356708
  19. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils.
    Biochim Biophys Acta. 1980 Feb 21;628(1):69-75 PMID: 7357030
  20. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF).
    Clin Immunol Immunopathol. 1980 Mar;15(3):318-330 PMID: 7371225
  21. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.
    J Biol Chem. 1980 Jun 25;255(12):5514-6 PMID: 7380824
  22. Release, purification, and characterization of platelet-activating factor (PAF).
    Biochimie. 1980;62(4):251-9 PMID: 17941181
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/jci110108
Published
1981-03-00
Pages
903-6
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC370642
Subset
IM
Grants
NHLBI NIH HHS · HL-07350 · United States
NHLBI NIH HHS · HL-22555 · United States
External Links
PubMed source DOI: 10.1172/jci110108 PMC Full Text View journal details
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