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PMID: 720385
Published · ppublish
English
Journal Article
Influence of GABA receptor agonists and antagonists on the binding of 3H-diazepam to the benzodiazepine receptor.
Abstract
The GABA receptor agonists, GABA and muscimol, increased, while the GABA receptor antagonist, (+)-bicuculline, decreased the affinity of the benzodiazepine receptor for 3H-diazepam. The effect was seen at both 0 and 25 degrees C in spite of a large difference of affinity for 3H-diazepam at the two temperatures.
MeSH Terms
Animals
Benzodiazepines/metabolism
Bicuculline/pharmacology
Brain/metabolism
Diazepam/metabolism
GABA Antagonists
In Vitro Techniques
Muscimol/pharmacology
Rats
Receptors, Drug/metabolism
gamma-Aminobutyric Acid/metabolism,pharmacology
Chemicals
GABA Antagonists
Receptors, Drug
Benzodiazepines
Muscimol
gamma-Aminobutyric Acid
Diazepam
Bicuculline
Article Info
Journal
European journal of pharmacology
Abbr.
Eur J Pharmacol
ISSN
0014-2999
Published
1978-11-01
Pages
129-32
Language
English
Region
Netherlands
NLM ID
1254354
Subset
IM
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