Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight.

The Journal of cell biology ·Vol. 90 ·No. 3 ·1981-09-00 ·Pages 727-31

Jaken S, Black PH

Abstract

The tumor promoter, phorbol myristate acetate (PMA), stimulates plasminogen activator production and extracellular release in confluent Swiss 3T3 cells. Coordinated with the increased extracellular release is a redistribution of the activity into plasma membrane-enriched fractions and a shift in the predominant molecular weight species from 75,000 to 49,000 daltons. The evidence suggests that PMA induces the formation of the 49,000 dalton species which is preferentially located in plasma membrane-enriched fractions.

MeSH Terms

Animals Cell Line Cell Membrane/metabolism Intracellular Membranes/metabolism Mice Molecular Weight Phorbols/pharmacology Plasminogen Activators/metabolism Tetradecanoylphorbol Acetate/pharmacology Time Factors

Chemicals

Phorbols Plasminogen Activators Tetradecanoylphorbol Acetate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jaken S

Black P H

References (16)

16 references, click to expand

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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.90.3.727

Published

1981-09-00

Pages

727-31

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2111890

Subset

External Links

PubMed source DOI: 10.1083/jcb.90.3.727 PMC Full Text View journal details

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Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight.

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