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PMID: 7177112 Published · ppublish English Journal Article

Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.

Molecular and cellular biology ·Vol. 2 ·No. 10 ·1982-10-00 ·Pages 1295-8

Cheetham BF, Shaw DC, Bellett AJ

Abstract

Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.

MeSH Terms
Adenoviruses, Human/physiology Animals Antigens, Viral/analysis Cell Cycle/drug effects Cell Transformation, Viral Cells, Cultured DNA Replication Enzyme Induction/drug effects Mitoguazone/pharmacology Polyamines/physiology Rats Thymidine Kinase/biosynthesis
Chemicals
Antigens, Viral Polyamines Thymidine Kinase Mitoguazone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cheetham B F
Shaw D C
Bellett A J
References (18)
18 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.2.10.1295-1298.1982
Published
1982-10-00
Pages
1295-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC369929
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.2.10.1295-1298.1982 PMC Full Text View journal details
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