Similar chromosomal abnormalities in several retinoblastomas.

Human genetics ·Vol. 61 ·No. 3 ·1982-00-00 ·Pages 201-4

Kusnetsova LE, Prigogina EL, Pogosianz HE, Belkina BM

Abstract

The study of banded chromosomes of nine sporadic unilateral retinoblastomas revealed near diploid karyotypes with multiple numerical and (or) structural abnormalities in all tumors. An identical marker i(6p) was noted in cells of the modal class of six retinoblastomas. Extra copies of the short arm of chromosome 6 were observed in seven tumors: +i(6p) in 6 and +6q-in one. Less regular but repeated findings were a loss of one sex chromosome, and markers 1p+ and 17q+. The structure of these markers was not identical in different tumors. Abnormalities of chromosome 13 were not observed in tumor cells, nor in blood lymphocytes stimulated by PHA.

MeSH Terms

Aneuploidy Child, Preschool Chromosome Aberrations/genetics Chromosome Disorders Chromosomes, Human, 1-3 Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X Eye Neoplasms/genetics Female Humans Infant Karyotyping Male Retinoblastoma/genetics Sex Chromosome Aberrations/genetics

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kusnetsova L E

Prigogina E L

Pogosianz H E

Belkina B M

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16 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00296442

Published

1982-00-00

Pages

201-4

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00296442 View journal details

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Similar chromosomal abnormalities in several retinoblastomas.

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