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PMID: 7173304 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Pharmacokinetics and tolerance of slow-release indomethacin tablets in rheumatoid arthritis.

European journal of clinical pharmacology ·Vol. 23 ·No. 4 ·1982-10-00 ·Pages 349-51

Kaarela K, Lehtinen K, Mäkisara P, Holttinen K, Lamminsivu U, Gordin A

Abstract

The pharmacokinetics, efficacy and tolerance of a new formulation of slow-release indomethacin tablet were compared with those of a conventional indomethacin capsule in 30 patients with rheumatoid arthritis. The slow-release tablet was absorbed more slowly than the capsule (tmax 3.7 h and less than 2 h, respectively) and produced more even serum drug levels in 10 subjects. Side-effects, especially dizziness and diarrhoea, were less frequent after the slow-release tablet than during the capsule period.

MeSH Terms
Adult Aged Arthritis, Rheumatoid/drug therapy Delayed-Action Preparations Digestive System/drug effects Drug Tolerance Female Humans Indomethacin/administration & dosage,adverse effects,blood,metabolism Kinetics Male Middle Aged Tablets
Chemicals
Delayed-Action Preparations Tablets Indomethacin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kaarela K
Lehtinen K
Mäkisara P
Holttinen K
Lamminsivu U
Gordin A
References (6)
6 references, click to expand
  1. [Bioavailability of indomethacin. Study of a delayed-action preparation].
    Rev Rhum Mal Osteoartic. 1979 Jul-Sep;46(7-9):505-8 PMID: 583080
  2. Indomethacin in rheumatoid arthritis: clinical effects, pharmacokinetics, and platelet studies in responders and nonresponders.
    Ann Rheum Dis. 1979 Apr;38(2):128-36 PMID: 375848
  3. Sustained release indomethacin: a double blind comparison with indomethacin suppositories.
    N Z Med J. 1981 Apr 22;93(682):261-2 PMID: 7019782
  4. Clinical Pharmacokinetics of indomethacin.
    Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58 PMID: 7249487
  5. A comparison of the pharmacokinetics of piroxicam with those of plain and slow release indomethacin. A crossover study.
    Eur J Rheumatol Inflamm. 1981;4(3):298-302 PMID: 6242949
  6. [Clinico-pharmacological investigation of an oral form of a depot preparation on silicone resin base with indomethacin as the active ingredient].
    Z Gesamte Inn Med. 1980 May 1;35(9):366-70 PMID: 7434845
Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
DOI
10.1007/BF00613619
Published
1982-10-00
Pages
349-51
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00613619 View journal details
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