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PMID: 7172512 Published · ppublish English Journal Article

High titres of anti-T antibodies and other haemagglutinins in human malaria.

Clinical and experimental immunology ·Vol. 50 ·No. 1 ·1982-10-00 ·Pages 83-91

Zouali M, Druilhe P, Gentilini M, Eyquem A

Abstract

The prevalence of antibodies against (i) human red blood cells (RBC) of A and B groups, (ii) trypsinized O Rh+ RBC and (iii) neuraminidase treated O Rh+ RBC were investigated both in sera of Africans from a malaria endemic area of Upper Volta and in sera of Europeans with acute malaria from a Paris hospital. An increased frequency of high titres of haemagglutinins was observed against A and B as well as O Rh+ trypsinized human RBC, thus confirming previously published results. In addition, agglutination of neuraminidase treated RBC showed that the titres were increased in about 40% of Africans studied and in about 80% of patients with acute malaria. Using agglutination with a specific anti-T lectin and inhibition with two ligands, it was found that sera of malarious patients contain high titres of antibodies directed against the T antigen of neuraminidase treated RBC. The mechanisms of appearance of high titres of autohaemagglutinins in malaria and their possible interference in the anaemia associated with this disease are discussed.

MeSH Terms
ABO Blood-Group System/immunology Acute Disease Antibody Specificity Antigens/immunology Antigens, Tumor-Associated, Carbohydrate Autoantibodies/analysis Hemagglutination/drug effects Hemagglutinins/analysis Humans Malaria/immunology Neuraminidase/pharmacology Trypsin/pharmacology
Chemicals
ABO Blood-Group System Antigens Antigens, Tumor-Associated, Carbohydrate Autoantibodies Hemagglutinins Thomsen-Friedenreich antigen Neuraminidase Trypsin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zouali M
Druilhe P
Gentilini M
Eyquem A
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1982-10-00
Pages
83-91
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1536851
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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