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PMID: 7150268 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles.

The Biochemical journal ·Vol. 206 ·No. 3 ·1982-09-15 ·Pages 641-5

McGrath JA, Goldspink DF

Abstract

The direct actions of glucocorticoid hormones on protein turnover were studied in isolated soleus muscles. These steroids were found to decrease the rates of both protein synthesis and protein breakdown within 3 h and 4 h respectively. Synthetic steroids (e.g. dexamethasone) were found to be more potent than naturally secreted hormones (e.g. cortisol) in inducing these changes, but only at concentrations in vitro less than 10nm.

MeSH Terms
Animals Corticosterone/pharmacology Dexamethasone/pharmacology Dose-Response Relationship, Drug Hydrocortisone/pharmacology In Vitro Techniques Male Muscle Proteins/metabolism Muscles/drug effects Rats Time Factors Triamcinolone Acetonide/pharmacology
Chemicals
Muscle Proteins Dexamethasone Triamcinolone Acetonide Corticosterone Hydrocortisone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McGrath J A
Goldspink D F
References (22)
22 references, click to expand
  1. The binding of dexamethasone and triamcinolone acetonide to glucocorticoid receptors in rat skeletal muscle.
    J Biol Chem. 1974 Aug 25;249(16):5236-40 PMID: 4369267
  2. Properties of muscle and liver lysosomes in adrenalectomized rats.
    Acta Physiol Scand. 1970 Jul;79(3):335-50 PMID: 5450409
  3. Relative changes in the function of muscle ribosomes and mitochondria during the early phase of steroid-induced catabolism.
    Biochem J. 1972 May;127(5):881-92 PMID: 5076236
  4. Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of N tau-methylhistidine.
    Biochem J. 1979 Jan 15;178(1):139-46 PMID: 435272
  5. Incorporation of C14-amino acids into protein of isolated diaphragms: role of the adrenal steroids.
    Am J Physiol. 1959 Nov;197:1089-92 PMID: 13845920
  6. Corticosteroids and growth.
    N Engl J Med. 1976 Sep 2;295(10):547-52 PMID: 950961
  7. The sedimentation of rat skeletal-muscle ribosomes. Effect of hydrocortisone, insulin and diet.
    Biochem J. 1968 Feb;106(4):913-9 PMID: 5637371
  8. A fluorometric method for the estimation of tyrosine in plasma and tissues.
    J Lab Clin Med. 1957 Nov;50(5):733-6 PMID: 13476030
  9. Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues.
    Am J Physiol. 1975 Jan;228(1):310-7 PMID: 1147022
  10. Mechanism of action of glucocorticoids.
    Metabolism. 1974 Feb;23(2):159-202 PMID: 4359315
  11. Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children.
    N Engl J Med. 1956 Apr 5;254(14):636-41 PMID: 13309649
  12. Binding of dexamethasone and cortisol to cytosol receptors in rat extensor digitorum longus and soleus muscles.
    Exp Neurol. 1977 Nov;57(2):342-8 PMID: 908377
  13. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.
    J Biol Chem. 1975 Jan 10;250(1):290-8 PMID: 1141208
  14. The effect of cortisone on protein breakdown and synthesis in rat skeletal muscle.
    Mol Cell Endocrinol. 1977 Jan;6(3):159-69 PMID: 832761
  15. Effect of glucocorticoids on plasma insulin.
    N Engl J Med. 1966 Jun 2;274(22):1237-41 PMID: 5935423
  16. Protein turnover in skeletal muscle. II. Effects of denervation and cortisone on protein catabolism in skeletal muscle.
    J Biol Chem. 1969 Jun 25;244(12):3223-9 PMID: 5792658
  17. The effects of cortisone treatment on the protein turnover of the soleus muscle after immobilization.
    Biochem Soc Trans. 1978;6(5):1017-9 PMID: 744307
  18. Effects of glucocorticoids on muscle protein turnover in perfused rat hemicorpus.
    Am J Physiol. 1980 Jun;238(6):E564-72 PMID: 6155787
  19. Role of protein synthesis in the inhibitory action of adrenal steroid hormones on amino acid transport by muscle.
    Endocrinology. 1966 Sep;79(3):531-40 PMID: 5922923
  20. Some biochemical effects of triamcinolone acetonide on rat liver and muscle.
    Biochem J. 1970 Feb;116(3):349-55 PMID: 5435682
  21. Thyroid hormones and muscle protein turnover. The effect of thyroid-hormone deficiency and replacement in thryoidectomized and hypophysectomized rats.
    Biochem J. 1981 Mar 15;194(3):771-82 PMID: 6171261
  22. Effect of corticosterone and its route of administration on muscle protein breakdown, measured in vivo by urinary excretion of N tau-methylhistidine in rats: response to different levels of dietary protein and energy.
    Metabolism. 1981 Aug;30(8):798-804 PMID: 7266373
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2060641
Published
1982-09-15
Pages
641-5
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1158634
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2060641 PMC Full Text View journal details
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