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PMID: 7150266 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Acute effects of glucagon on citrulline biosynthesis.

The Biochemical journal ·Vol. 206 ·No. 3 ·1982-09-15 ·Pages 627-31

Rabier D, Briand P, Petit F, Parvy P, Kamoun P, Cathelineau L

Abstract

Mitochondria isolated from livers of rats fed on different diets showed altered capacity to synthesize citrulline. Glucagon, 15 min after injection, increases citrulline biosynthesis, except after the high-protein diet. A significant correlation between citrulline biosynthesis and N-acetylglutamate content with and without glucagon treatment was shown when rats were fed on a standard or a carbohydrate diet. Different diets modified carbamoyl phosphate synthetase I (EC 6.3.4.16) and N-acetylglutamate synthase (acetyl-CoA:L-glutamate N-acetyltransferase, EC 2.3.1.1) activities. Glucagon did not modify these activities.

MeSH Terms
Animals Citrulline/biosynthesis Dietary Carbohydrates/pharmacology Dietary Fats/pharmacology Dietary Proteins/pharmacology Glucagon/pharmacology Glutamates/metabolism Male Mitochondria, Liver/drug effects,metabolism Rats Rats, Inbred Strains
Chemicals
Dietary Carbohydrates Dietary Fats Dietary Proteins Glutamates Citrulline Glucagon N-acetylglutamic acid
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rabier D
Briand P
Petit F
Parvy P
Kamoun P
Cathelineau L
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23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2060627
Published
1982-09-15
Pages
627-31
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1158632
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2060627 PMC Full Text View journal details
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