Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family.

Human genetics ·Vol. 61 ·No. 1 ·1982-00-00 ·Pages 36-8

Bruun-Petersen G, Lamm LU, Jacobsen BK, Kristensen T

Abstract

A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F*3 C4F*2.2 is composed of two C4F alleles and the other C4S*5.1 C4S*1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB*35, Bf*F, and HLAD/DR*1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(A+) variant.

MeSH Terms

Adult Child Complement C4/genetics Electrophoresis Female Genes Humans Male Pedigree Phenotype

Chemicals

Complement C4

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bruun-Petersen G

Lamm L U

Jacobsen B K

Kristensen T

References (8)

8 references, click to expand

Two HLA-linked loci controlling the fourth component of human complement.
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5165-9 PMID: 368809
Human complement C4 locus is duplicated on some chromosomes.
Nature. 1979 Jun 21;279(5715):736-7 PMID: 450123
Inherited structural polymorphism of the fourth component of human complement.
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3576-80 PMID: 6932037
Chido and Rodgers blood groups are distinct antigenic components of human complement C4.
Nature. 1978 Jun 22;273(5664):668-70 PMID: 78453
Family studies of complement C4 and HLA in man.
Hum Genet. 1981;58(3):260-7 PMID: 6948763
Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6.
Nature. 1976 Nov 18;264(5583):253-4 PMID: 1088823
C4 haplotype products and partial inhibition of anti-Rodgers sera.
J Immunogenet. 1981 Dec;8(6):485-91 PMID: 7334218
The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.
J Exp Med. 1977 Nov 1;146(5):1380-9 PMID: 925607

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291328

Published

1982-00-00

Pages

36-8

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00291328 View journal details

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Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family.

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