An oral preparation to release drugs in the human colon.

British journal of clinical pharmacology ·Vol. 14 ·No. 3 ·1982-09-00 ·Pages 405-8

Dew MJ, Hughes PJ, Lee MG, Evans BK, Rhodes J

Abstract

1 A colonic delivery system is described to deliver orally ingested drugs to the colon and release them at that site by coating with an acrylic based resin (Eudragit S). The technique is validated using X-ray evidence and serum levels of a convenient marker, sulphapyridine. 2 This colonic delivery system is particularly suitable for drugs such as 5-amino salicylic acid or steroids in the management of patients with colitis.

MeSH Terms

Aminosalicylic Acids/metabolism Capsules Colon/metabolism Delayed-Action Preparations Digestive System/diagnostic imaging Female Humans Male Mesalamine Middle Aged Radiography Sulfapyridine/metabolism

Chemicals

Aminosalicylic Acids Capsules Delayed-Action Preparations Mesalamine Sulfapyridine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Dew M J

Hughes P J

Lee M G

Evans B K

Rhodes J

References (10)

10 references, click to expand

The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.
J Pharmacol Exp Ther. 1972 Jun;181(3):555-62 PMID: 4402374
The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients.
Gut. 1973 Aug;14(8):631-41 PMID: 4147555
A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin).
Gut. 1973 Dec;14(12):923-6 PMID: 4150435
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device.
Gut. 1974 Dec;15(12):999-1004 PMID: 4448417
An experiment to determine the active therapeutic moiety of sulphasalazine.
Lancet. 1977 Oct 29;2(8044):892-5 PMID: 72239
Male infertility due to sulphasalazine.
Lancet. 1979 Aug 11;2(8137):276-8 PMID: 88609
Effect of sulphapyridine, 5-aminosalicylic acid, and placebo in patients with idiopathic proctitis: a study to determine the active therapeutic moiety of sulphasalazine.
Gut. 1980 Jul;21(7):632-5 PMID: 6107263
Sulphasalazine and male infertility: reversibility and possible mechanism.
Gut. 1981 Jun;22(6):445-51 PMID: 6114897
Retrograde colonic spread of enemata in ulcerative colitis.
Br Med J. 1961 Sep 2;2(5252):614-6 PMID: 13768325
PREDNISONE AS MAINTENANCE TREATMENT FOR ULCERATIVE COLITIS IN REMISSION.
Lancet. 1965 Jan 23;1(7378):188-9 PMID: 14238045

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1982.tb01999.x

Published

1982-09-00

Pages

405-8

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1427636

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1982.tb01999.x PMC Full Text View journal details

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An oral preparation to release drugs in the human colon.

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