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题目:: Replicative potential of individual cell hybrids derived from young and old donor human skin fibroblasts.
作者:: Muggleton-Harris(A L),Aroian(M A)
状态:: 发布时间1982-09-24 , 更新时间 2008-11-21
期刊:: Somatic Cell Genet
摘要:: Neonatal, adult, and aged donor human skin fibroblast cell cultures have been characterized for the population doubling potential and in vitro-in vivo relationship. Hybrid cells derived from individual whole-cell fusions of replicating GRC 387 (aged) and CSC 303 (neonatal) cells demonstrated that an intermediate mode of replication between that of the two parental cell lines occurred; therefore the longevity of the aged fibroblast cells was enhanced. The GRC 387 cells have an extended post-replicative phase-out period in comparison with the CSC 303 cells, and the experimental hybrids demonstrated a 20-25% increase of the period over that of the GRC 387 cells.
语言:: eng
DOI:

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