Structure elucidation of mammalian TCDD-metabolites.

Experientia ·Vol. 38 ·No. 4 ·1982-04-15 ·Pages 484-6

Poiger H, Buser HR, Weber H, Zweifel U, Schlatter C

Abstract

Thin layer and gas chromatographic examination of the bile of dogs which were given tritium-labelled TCDD revealed the presence of several polar biotransformation products. The structure of 5 phenolic metabolites was elucidated by combined gas chromatography-mass spectrometry. A metabolic breakdown scheme for TCDD in the dog is proposed.

MeSH Terms

Animals Bile/metabolism Biotransformation Chromatography, Thin Layer Dioxins/metabolism Dogs Mass Spectrometry Polychlorinated Dibenzodioxins/metabolism

Chemicals

Dioxins Polychlorinated Dibenzodioxins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Poiger H

Buser H R

Weber H

Zweifel U

Schlatter C

References (7)

7 references, click to expand

Toxicology of chlorinated dibenzo-p-dioxins.
Environ Health Perspect. 1973 Sep;5:87-99 PMID: 4270944
Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.
Experientia. 1972 Oct 15;28(10):1129-49 PMID: 4117670
Studies on the bioaccumulation and microbial degradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Environ Health Perspect. 1973 Sep;5:253-8 PMID: 4127619
Identification of hydroxylated chlorodibenzo-p-dioxins, chlorodibenzofurans, chlorodiphenyl ethers and chloronaphthalenes as their methyl ethers by gas chromatography mass spectrometry.
Biomed Mass Spectrom. 1978 Mar;5(3):224-31 PMID: 630064
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster.
Toxicol Appl Pharmacol. 1980 Aug;55(1):67-78 PMID: 7423509
Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster.
Toxicol Appl Pharmacol. 1980 Oct;56(1):78-85 PMID: 7444968
Biological degradation of TCDD in rats.
Nature. 1979 Oct 25;281(5733):706-7 PMID: 551291

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01952652

Published

1982-04-15

Pages

484-6

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01952652

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Structure elucidation of mammalian TCDD-metabolites.

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