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PMID: 7082312 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effects of chronic metabolic acidosis on liver and muscle glutamine metabolism in the dog in vivo.

The Biochemical journal ·Vol. 202 ·No. 1 ·1982-01-15 ·Pages 271-3

Fine A

Abstract

1. Chronic HCl acidosis was induced in dogs. 2. Hepatic extraction of glutamine fell compared with normal animals. 3. Muscle glutamine production was unchanged in acidosis. 4. The results are discussed in relation to inter-organ glutamine metabolism in acidosis in vivo.

MeSH Terms

Acidosis/metabolism Animals Chronic Disease Dogs Female Glutamine/metabolism Liver/metabolism Male Muscles/metabolism

Chemicals

Glutamine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Fine A

References (9)

9 references, click to expand

Studies on the transport of glutamate in Ehrlich cells--inhibition by other amino acids and stimulation by H-ions.
Biochem Z. 1965 Sep 30;342(5):542-52 PMID: 5893748
The effect of perfusate pH on glutamine metabolism in the isolated perfused rat liver.
J Biol Chem. 1970 Oct 25;245(20):5491-7 PMID: 5469177
Metabolism of glutamine by the intact functioning kidney of the dog. Studies in metabolic acidosis and alkalosis.
J Clin Invest. 1972 Mar;51(3):557-65 PMID: 5011100
The formation of glutamine and alanine in skeletal muscle.
J Biol Chem. 1974 Sep 10;249(17):5500-6 PMID: 4278315
Identification of ketone bodies and glutamine as the major respiratory fuels in vivo for postabsorptive rat small intestine.
J Biol Chem. 1978 Jan 10;253(1):69-76 PMID: 618869
A role for bicarbonate in the regulation of mammalian glutamine metabolism.
Biochem J. 1979 Dec 15;184(3):599-606 PMID: 540052
Glutamine release from hindlimb and uptake by kidney in the acutely acidotic rat.
Biochem J. 1980 May 15;188(2):557-60 PMID: 7396881
Interorgan relationships for glutamine metabolism in normal and acidotic rats.
Am J Physiol. 1981 May;240(5):E519-25 PMID: 7235007
RENAL PRODUCTION AND EXCRETION OF AMMONIA.
Am J Med. 1964 May;36:720-42 PMID: 14144403

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2020271

Published

1982-01-15

Pages

271-3

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1158103

Subset

External Links

PubMed source DOI: 10.1042/bj2020271 PMC Full Text View journal details

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The effects of chronic metabolic acidosis on liver and muscle glutamine metabolism in the dog in vivo.

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