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PMID: 7074191 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interactions between neutral phospholipid bilayer membranes.

Biophysical journal ·Vol. 37 ·No. 3 ·1982-03-00 ·Pages 657-65

Lis LJ, McAlister M, Fuller N, Rand RP, Parsegian VA

Abstract

We have obtained force vs. separation relations between bilayers in 10 different phospholipid preparations: dilauroyl-dimyristoyl-, dipalmitoyl-, distearoyl-, or dioleoylphosphatidylcholine (PC); egg phosphatidylethanolamine; cholesterol-containing bilayers of dipalmitoyl PC and of egg PC. The chemical potential of water in the multilamellar lattice is determined at all water contents and changes continuously with bilayer separation; no discrete classes of water are observed. The interbilayer van der Waals force is estimated from the balance of forces at the bilayer separation where the multilayer lattice is in equilibrium with pure water. Although quantitative differences are evident for different phospholipids, all force curves but one show a clear, exponentially decaying "hydration "repulsion" whose decay distance is 2-3 A . Estimates of forces between bilayer vesicles show great sensitivity to the identity of the phospholipid polar group and to the packing of the hydrocarbon acyl chains. On major implication of this is the likelihood of local structural changes and lipid segregation in the area of closest approach of interacting vesicles of mixed phospholipids.

MeSH Terms
Chemical Phenomena Chemistry, Physical Cholesterol/metabolism Lipid Bilayers/metabolism Phospholipids/metabolism Water/metabolism
Chemicals
Lipid Bilayers Phospholipids Water Cholesterol
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lis L J
McAlister M
Fuller N
Rand R P
Parsegian V A
References (44)
44 references, click to expand
  1. Osmotic shrinkage of giant egg-lecithin vesicles.
    Biophys J. 1981 Apr;34(1):95-109 PMID: 7213933
  2. Evidence for a role of phosphatidyl ethanolamine as a modulator of membrane-membrane contact.
    J Membr Biol. 1979 Jun 29;48(1):95-114 PMID: 40031
  3. Adsorption of divalent cations to a variety of phosphatidylcholine bilayers.
    Biochemistry. 1981 Mar 31;20(7):1771-7 PMID: 7225357
  4. Water in biological membranes: adsorption isotherms and circular dichroism as a function of hydration.
    J Membr Biol. 1972;9(2):127-40 PMID: 5084456
  5. Binding of divalent cations of dipalmitoylphosphatidylcholine bilayers and its effect on bilayer interaction.
    Biochemistry. 1981 Mar 31;20(7):1761-70 PMID: 6164391
  6. Synthesis of lecithins by acylation of O-(sn-glycero-3-phosphoryl) choline with fatty acid anhydrides.
    Biochim Biophys Acta. 1969 Dec 17;187(4):520-6 PMID: 5362514
  7. Interaction of red blood cells with a polarized electrode: evidence of long-range intermolecular forces.
    Biophys J. 1976 Oct;16(10):1131-53 PMID: 822894
  8. Nonsolvent water in liposomes.
    J Membr Biol. 1974;17(1):87-100 PMID: 4858130
  9. Equilibrium studies of lecithin-cholesterol interactions I. Stoichiometry of lecithin-cholesterol complexes in bulk systems.
    Biophys J. 1978 Jun;22(3):469-88 PMID: 667296
  10. Thermodynamic constants for nonelectrolyte partition between dimyristoyl lecithin and water.
    J Membr Biol. 1974;17(2):101-20 PMID: 4407659
  11. Structure and polymorphism of the hydrocarbon chains of lipids: a study of lecithin-water phases.
    J Mol Biol. 1973 Apr 25;75(4):711-33 PMID: 4738730
  12. Van der Waals forces in biological systems.
    Q Rev Biophys. 1973 Nov;6(4):341-87 PMID: 4598034
  13. Nature of the Thermal pretransition of synthetic phospholipids: dimyristolyl- and dipalmitoyllecithin.
    Biochemistry. 1976 Oct 19;15(21):4575-80 PMID: 974077
  14. Models for the specific adhesion of cells to cells.
    Science. 1978 May 12;200(4342):618-27 PMID: 347575
  15. Phospholipid hydration studied by deuteron magnetic resonace spectroscopy.
    Chem Phys Lipids. 1974 Feb;12(1):1-16 PMID: 4856625
  16. Water and hermal diffusivity in a lipid-water smectic phase.
    Biophys J. 1978 Sep;23(3):427-49 PMID: 698346
  17. X-ray diffraction study in water of lipids extracted from human erythrocytes: the position of cholesterol in the lipid lamellae.
    Biophys J. 1968 Jan;8(1):125-37 PMID: 5641398
  18. Long-range attraction between red cells and a hydrocarbon surface.
    Nature. 1977 Aug 25;268(5622):767-9 PMID: 895882
  19. Anion diffusion selectivity in a pore model. The phosphatidylcholine-water lamellar phase.
    Biochim Biophys Acta. 1978 Feb 21;507(2):219-29 PMID: 626733
  20. Equilibrium studies of lecithin-cholesterol interactions. II. Phase relations in surface films: analysis of the "condensing" effect of cholesterol.
    Biophys J. 1978 Jun;22(3):489-500 PMID: 667297
  21. Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction.
    Biochim Biophys Acta. 1968 Apr 29;150(3):333-40 PMID: 5689845
  22. Apparent modification of forces between lecithin bilayers.
    Science. 1976 Jan 30;191(4225):399-400 PMID: 1246623
  23. Thermal analysis of lipids, proteins and biological membranes. A review and summary of some recent studies.
    Chem Phys Lipids. 1969 Dec;3(4):304-56 PMID: 4905514
  24. Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3862-6 PMID: 1069270
  25. The effect of cholesterol on measured interaction and compressibility of dipalmitoylphosphatidylcholine bilayers.
    Can J Biochem. 1980 Oct;58(10):959-68 PMID: 6893949
  26. Long-range physical forces in the biological milieu.
    Annu Rev Biophys Bioeng. 1973;2:221-55 PMID: 4583655
  27. INTERMOLECULAR FORCES AND BIOLOGICAL SPECIFICITY.
    Proc Natl Acad Sci U S A. 1963 Sep;50(3):516-24 PMID: 16578546
  28. Adsorption of divalent cations to bilayer membranes containing phosphatidylserine.
    J Gen Physiol. 1981 Apr;77(4):445-73 PMID: 7241089
  29. Measurement of repulsive forces between charged phospholipid bilayers.
    Biochemistry. 1978 Jul 25;17(15):3163-8 PMID: 698192
  30. Deuteron nuclear magnetic resonance studies of phase equilibria in a lecithin-water system.
    Biochemistry. 1977 Dec 27;16(26):5742-5 PMID: 579320
  31. Interpretation of nonelectrolyte partition coefficients between dimyristoyl lecithin and water.
    J Membr Biol. 1974;17(2):121-54 PMID: 4407798
  32. Kinetics of a Ca-2+-triggered membrane aggregation reaction of phospholipid membranes.
    Biochim Biophys Acta. 1975 Jul 3;394(3):335-47 PMID: 1131369
  33. Measurement and modification of forces between lecithin bilayers.
    Biophys J. 1977 May;18(2):209-30 PMID: 861359
  34. Measured work of deformation and repulsion of lecithin bilayers.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2750-4 PMID: 288063
  35. Effects of fusogenic agent on membrane structure of erythrocyte ghosts and the mechanism of membrane fusion.
    Nature. 1978 Feb 16;271(5646):672-4 PMID: 625336
  36. Interacting phospholipid bilayers: measured forces and induced structural changes.
    Annu Rev Biophys Bioeng. 1981;10:277-314 PMID: 7020577
  37. Thermotropic transitions in biomembranes.
    Annu Rev Biophys Bioeng. 1976;5:205-38 PMID: 182064
  38. Interactions of liposomes with mammalian cells.
    Annu Rev Biophys Bioeng. 1978;7:435-68 PMID: 352245
  39. Coexistence of rigid crystalline and liquid crystalline phases in lecithin-water mixtures.
    Biophys J. 1974 May;14(5):335-42 PMID: 4836034
  40. Studies on the mechanism of membrane fusion: evidence for an intermembrane Ca2+-phospholipid complex, synergism with Mg2+, and inhibition by spectrin.
    Biochemistry. 1979 Mar 6;18(5):780-90 PMID: 420815
  41. Red blood cell adhesion. III. Analysis of forces.
    J Cell Sci. 1980 Feb;41:151-7 PMID: 7364879
  42. Studies on the mechanism of membrane fusion: kinetics of calcium ion induced fusion of phosphatidylserine vesicles followed by a new assay for mixing of aqueous vesicle contents.
    Biochemistry. 1980 Dec 23;19(26):6011-21 PMID: 7470445
  43. Studies on the mechanism of membrane fusion. Role of head-group composition in calcium- and magnesium-induced fusion of mixed phospholipid vesicles.
    Biochim Biophys Acta. 1981 Mar 20;642(1):182-95 PMID: 7225377
  44. Measurement of forces between lecithin bilayers.
    Nature. 1976 Feb 19;259(5544):601-3 PMID: 1250410
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
Published
1982-03-00
Pages
657-65
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1328851
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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