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PMID: 7068832 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Problems associated with counterimmunoelectrophoresis assays for detecting Clostridium difficile toxin.

Journal of clinical microbiology ·Vol. 15 ·No. 2 ·1982-02-00 ·Pages 347-9

West SE, Wilkins TD

Abstract

The antitoxins currently used for the detection of Clostridium difficile by counterimmunoelectrophoresis react with other C. difficile antigens in addition to the toxins produced by the bacterium.

MeSH Terms
Antigens, Bacterial/immunology Antitoxins/immunology Bacterial Toxins/analysis Clostridium/immunology,pathogenicity Counterimmunoelectrophoresis/methods Immunoelectrophoresis/methods
Chemicals
Antigens, Bacterial Antitoxins Bacterial Toxins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
West S E
Wilkins T D
References (14)
14 references, click to expand
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    Lancet. 1977 Nov 26;2(8048):1103-6 PMID: 73011
  2. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.
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  4. Clostridium difficile and the aetiology of pseudomembranous colitis.
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  5. Clindamycin-induced enterocolitis in hamsters as a model of pseudomembranous colitis in patients.
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  6. A non-barbital buffer for immunoelectrophoresis and zone electrophoresis in agarose gels.
    Clin Chem. 1978 Oct;24(10):1825-7 PMID: 568042
  7. Selective and differential medium for isolation of Clostridium difficile.
    J Clin Microbiol. 1979 Feb;9(2):214-9 PMID: 429542
  8. Aetiology of antimicrobial-agent-associated colitis.
    Lancet. 1978 Apr 15;1(8068):802-3 PMID: 85818
  9. Cytotoxicity assay in antibiotic-associated colitis.
    J Infect Dis. 1979 Nov;140(5):765-70 PMID: 231071
  10. Identification of toxigenic Clostridium difficile by counterimmunoelectrophoresis.
    J Clin Microbiol. 1980 May;11(5):470-3 PMID: 7381011
  11. Production of Clostridium difficile antitoxin.
    Infect Immun. 1980 Jun;28(3):1041-3 PMID: 7399686
  12. Clinical and laboratory observations in Clostridium difficile colitis.
    Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521-6 PMID: 7435423
  13. Rapid detection of Clostridium difficile toxin in human feces.
    J Clin Microbiol. 1980 Dec;12(6):776-9 PMID: 7031079
  14. Immunological analysis of the EDTA-soluble antigens of Clostridium difficile and related species.
    J Gen Microbiol. 1981 Jan;122(1):41-6 PMID: 6798159
Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.15.2.347-349.1982
Published
1982-02-00
Pages
347-9
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC272093
Subset
IM
Grants
NIAID NIH HHS · AI-15749-02 · United States
External Links
PubMed source DOI: 10.1128/jcm.15.2.347-349.1982 PMC Full Text View journal details
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