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PMID: 7059968 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Reduction of ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves by nerve growth factor.

Cancer research ·Vol. 42 ·No. 3 ·1982-03-00 ·Pages 1038-40

Vinores SA, Koestner A

Abstract

Ethylnitrosourea administered to pregnant rats on the 21st day of gestation at a dose of 50 mg/kg resulted in early neoplastic proliferation or neurinomas of trigeminal nerves in 90% of the offspring at 90 days of age. Treatment with nerve growth factor either postnatally following ethylnitrosourea administration or transplacentally prior to ethylnitrosourea treatment appeared to result in a reduction of neurinomas at 90 days of age.

MeSH Terms

Age Factors Animals Cranial Nerve Neoplasms/chemically induced,pathology Ethylnitrosourea Female Gestational Age Maternal-Fetal Exchange Neoplasms, Experimental/chemically induced Nerve Growth Factors/administration & dosage Neurilemmoma/chemically induced,pathology Nitrosourea Compounds Precancerous Conditions/chemically induced,pathology Pregnancy Rats Trigeminal Nerve

Chemicals

Nerve Growth Factors Nitrosourea Compounds Ethylnitrosourea

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Vinores S A

Koestner A

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1982-03-00

Pages

1038-40

Language

English

Region

United States

NLM ID

2984705R

Subset

Grants

NCI NIH HHS · CA 11224 · United States

NCI NIH HHS · CA 20348 · United States

NINDS NIH HHS · NS 07091 · United States

External Links

PubMed source View journal details

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Reduction of ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves by nerve growth factor.

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