Divergence of binding sites, in vitro action, and secretory regulation of the somatomedin peptides, IGF-I and IGF-II.

Amino Acid Sequence Animals Binding Sites Humans Insulin/analysis,metabolism,physiology Insulin-Like Growth Factor I Insulin-Like Growth Factor II Nonsuppressible Insulin-Like Activity/metabolism Peptides/analysis,metabolism,physiology Rats Somatomedins/analysis,metabolism,physiology Structure-Activity Relationship

Insulin Nonsuppressible Insulin-Like Activity Peptides Somatomedins Insulin-Like Growth Factor I Insulin-Like Growth Factor II