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PMID: 7045590 Published · ppublish English Journal Article

Damage to DNA induces expression of the ruv gene of Escherichia coli.

Molecular & general genetics : MGG ·Vol. 185 ·No. 2 ·1982-00-00 ·Pages 352-5

Shurvinton CE, Lloyd RG

Abstract

Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. Beta-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of beta-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed.

MeSH Terms
Bacterial Proteins/physiology Coliphages/genetics DNA Repair DNA, Bacterial/radiation effects Escherichia coli/genetics,radiation effects Gene Expression Regulation Genes, Bacterial Rec A Recombinases Recombination, Genetic Serine Endopeptidases Ultraviolet Rays
Chemicals
Bacterial Proteins DNA, Bacterial LexA protein, Bacteria Rec A Recombinases Serine Endopeptidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shurvinton C E
Lloyd R G
References (21)
21 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00330811
Published
1982-00-00
Pages
352-5
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00330811
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