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PMID: 7042643 Published · ppublish English Journal Article

Creutzfeldt-Jakob disease and sheep brain. A report from central and Southern Italy.

Italian journal of neurological sciences ·Vol. 1 ·No. 3 ·1980-06-00 ·Pages 171-4

Lo Russo F, Neri G, Figà-Talamanca L

Abstract

The places of origin of 7 out of 8 patients with CJD coincide with the distribution of sheep-rearing in central and southern Italy, confirming the suggested link between this disease and eating and-or handling sheep CNS tissue. Since 6 of the 8 cases were women, it seems more likely that the virus responsible for CJD enters the body through a break in the skin of the hands and forearms in the process of foodhandling rather than via the Digestive tract. This aspect should be borne in mind when investigating the problems of CJD transmission.

MeSH Terms
Aged Animal Husbandry Animals Brain Creutzfeldt-Jakob Syndrome/epidemiology,transmission Diet/adverse effects Female Food Handling Humans Italy Male Middle Aged Sheep Sheep Diseases/transmission
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lo Russo F
Neri G
Figà-Talamanca L
References (12)
12 references, click to expand
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    Ann Neurol. 1979 Feb;5(2):189-92 PMID: 371521
  2. Creutzfeldt-Jakob disease in France: III. Epidemiological study of 170 patients dying during the decade 1968--1977.
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  3. Virology and neuroepidemiology: chronic viral infections of the nervous system.
    Adv Neurol. 1978;19:161-7 PMID: 369320
  4. Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering.
    Ann Neurol. 1979 Feb;5(2):177-88 PMID: 371520
  5. Creutzfeldt-Jakob disease: possible association with eating brains.
    N Engl J Med. 1977 Apr 7;296(14):820-1 PMID: 320486
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    N Engl J Med. 1975 Apr 24;292(17):927 PMID: 1090830
  7. Precautions in medical care of, and in handling materials from, patients with transmissible virus dementia (Creutzfeldt-Jakob disease).
    N Engl J Med. 1977 Dec 8;297(23):1253-8 PMID: 335248
  8. [Creutzfeldt-Jacob disease in continental France. Retrospective study from 1968 to 1977].
    Rev Neurol (Paris). 1979 Jun;135(5):439-43 PMID: 395612
  9. Creutzfeldt-Jakob disease: familial clustering among Libyan-born Israelis.
    Neurology. 1979 Feb;29(2):225-31 PMID: 372840
  10. More on Creutzfeldt-Jakob disease and sheep brain.
    N Engl J Med. 1977 Aug 25;297(8):453 PMID: 329136
  11. The clinical characteristics of transmissible Creutzfeldt-Jakob disease.
    Brain. 1973;96(1):1-20 PMID: 4633062
  12. Creutzfeldt-Jakob disease and sheep brain (cont.)
    N Engl J Med. 1977 Jun 16;296(24):1415 PMID: 323716
Article Info
Journal
Italian journal of neurological sciences
Abbr.
Ital J Neurol Sci
ISSN
0392-0461
DOI
10.1007/BF02335847
Published
1980-06-00
Pages
171-4
Language
English
Region
Italy
NLM ID
8006502
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02335847
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