Home LiteratureArticle Details
PMID: 7035362 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.

Infection and immunity ·Vol. 35 ·No. 2 ·1982-02-00 ·Pages 417-24

Chedid LA, Parant MA, Audibert FM, Riveau GJ, Parant FJ, Lederer E, Choay JP, Lefrancier PL

Abstract

Immunostimulant activities of muramyl dipeptide (enhancement of specific immune responses and of nonspecific resistance to infection) were retained by its N-acetylmuramyl-L-alanyl-D-glutaminyl-n-butyl ester derivative, although very large amounts administered intravenously, or even by the very sensitive intracerebroventricular route, did not elicit fever in the rabbit. This analog also appeared to be devoid of other secondary effects which have been observed after administration of muramyl dipeptide.

MeSH Terms
Acetylmuramyl-Alanyl-Isoglutamine/adverse effects,analogs & derivatives,immunology Adjuvants, Immunologic/adverse effects Animals Female Fever/chemically induced Glycopeptides/immunology Klebsiella Infections/immunology Klebsiella pneumoniae Leukocyte Count Limulus Test Liver Mice Mice, Inbred DBA Organ Size/drug effects Spleen
Chemicals
Adjuvants, Immunologic Glycopeptides Acetylmuramyl-Alanyl-Isoglutamine murabutide
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Chedid L A
Parant M A
Audibert F M
Riveau G J
Parant F J
Lederer E
Choay J P
Lefrancier P L
References (19)
19 references, click to expand
  1. Dirunal variations in rabbits: hematological parameters.
    Am J Physiol. 1970 Jun;218(6):1609-12 PMID: 5446289
  2. An immunological study of the diphtheria toxin molecule.
    Immunochemistry. 1972 Sep;9(9):891-906 PMID: 4116339
  3. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
    Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25 PMID: 4606813
  4. Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.
    Biken J. 1975 Jun;18(2):105-11 PMID: 1180867
  5. Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components.
    Cell Immunol. 1976 Feb;21(2):243-9 PMID: 1260863
  6. Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.
    Biken J. 1976 Mar;19(1):9-13 PMID: 779765
  7. Modulation of the immune response by a synthetic adjuvant and analogs.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5 PMID: 1065901
  8. Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.
    Proc Natl Acad Sci U S A. 1977 May;74(5):2089-93 PMID: 325566
  9. Gelation of the amoebocyte lysate of Tachypleus tridentatus by cell wall digest of several gram-positive bacteria and synthetic peptidoglycan subunits of natural and unnatural configurations.
    Biken J. 1977 Mar;20(1):5-10 PMID: 880206
  10. Correlation of stereochemically specific structure in muramyl dipeptide between macrophage activation and adjuvant activity.
    Biochem Biophys Res Commun. 1977 Jul 25;77(2):621-7 PMID: 901491
  11. Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.
    Proc Natl Acad Sci U S A. 1978 Jul;75(7):3395-9 PMID: 356054
  12. Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents.
    Prog Allergy. 1978;25:63-105 PMID: 362430
  13. The pyrogenicity of the synthetic adjuvant muramyl dipeptide and two structural analogues.
    J Infect Dis. 1978 Dec;138(6):760-7 PMID: 368262
  14. Enhancement of endotoxic shock by N-acetylmuramyl-L-alanyl-(L-seryl)-D-isoglutamine (muramyl dipeptide).
    Cancer Res. 1979 Nov;39(11):4756-9 PMID: 115579
  15. Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.
    Infect Immun. 1980 Mar;27(3):826-31 PMID: 7380554
  16. Central pyrogenic activity of muramyl dipeptide.
    J Exp Med. 1980 Oct 1;152(4):869-77 PMID: 7420023
  17. Muramyl dipeptide stimulation of particle clearance in several animal species.
    J Reticuloendothel Soc. 1980 Nov;28(5):457-71 PMID: 7441647
  18. Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide.
    J Infect Dis. 1980 Nov;142(5):708-15 PMID: 7462686
  19. [Study of the tolerance of adrenalectomized mice using an endotoxin labeled with Cr-51].
    Ann Inst Pasteur (Paris). 1961 Aug;101:170-7 PMID: 13692709
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.35.2.417-424.1982
Published
1982-02-00
Pages
417-24
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC351055
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.35.2.417-424.1982 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2