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PMID: 7028029 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus).

Biochemical genetics ·Vol. 19 ·No. 5-6 ·1981-06-00 ·Pages 431-44

Otto J, von Deimling O

Abstract

The heredity and linkage of gene loci were established for two different enzymes with esterproteolytic activity from mouse submandibular gland: protease A and protease E. Based upon strain distribution and biochemical properties of the two esterproteases, the existence of two corresponding structural loci is proposed: Prt-4 (protease A) and Prt-5 (protease E). Prt-4 and Prt-5 proved to be different from Tam-1. From a four-point-cross, the gene order Gpi-1-(Tam-1, Prt-4, Prt-5)-c is suggested. Thus a gene cluster was shown to exist on chromosome 7 coding for esterproteases, all of which are controlled by testosterone.

MeSH Terms

Alleles Animals Enzyme Induction Female Genetic Linkage Male Mice Mice, Inbred Strains Peptide Hydrolases/genetics Phenotype Species Specificity Submandibular Gland/enzymology Testosterone/pharmacology

Chemicals

Testosterone Peptide Hydrolases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Otto J

von Deimling O

References (13)

13 references, click to expand

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Article Info

Journal

Biochemical genetics

Abbr.

Biochem Genet

ISSN

0006-2928

DOI

10.1007/BF00484616

Published

1981-06-00

Pages

431-44

Language

English

Region

United States

NLM ID

0126611

Subset

External Links

PubMed source DOI: 10.1007/BF00484616 View journal details

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Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus).

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