Home LiteratureArticle Details
PMID: 7013719 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Significance of fibronectin in rheumatoid arthritis and osteoarthrosis.

Annals of the rheumatic diseases ·Vol. 40 ·No. 2 ·1981-04-00 ·Pages 142-53

Scott DL, Wainwright AC, Walton KW, Williamson N

Abstract

Fibronectin is a glycoprotein secreted by connective tissue cells into their environment and into the blood. Plasma fibronectin has been isolated and used to prepare an antiserum. This has been shown to be specific for fibronectin and unreactive with fibrin(ogen) and collagen, to which fibronectin binds in vitro. The antiserum has been used to examine the distribution of this protein in the synovium in health, in rheumatoid arthritis, and in osteoarthrosis, and to estimate levels in plasma and synovial fluid. The results suggest that fibronectin is synthesised by synovial cells, and the synovial fluid level of fibronectin was found to be about twice the plasma level in rheumatoid arthritis. In long-standing arthritis fibronectin was also found to be codistributed with (presumably by adsorption upon) fibrin and immature collagen in intra-articular structures but was no longer demonstrable in areas where mature collagen had been formed in areas undergoing fibrosis. The possible significance of local fibronectin production within joints in relation to its possible effect on the resolution or continuance of arthritis is discussed.

MeSH Terms
Adult Aged Arthritis, Rheumatoid/metabolism Female Fibronectins/blood,metabolism Fluorescent Antibody Technique Humans Immunoenzyme Techniques Male Middle Aged Osteoarthritis/metabolism Synovial Fluid/analysis Synovial Membrane/metabolism
Chemicals
Fibronectins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Scott D L
Wainwright A C
Walton K W
Williamson N
References (32)
32 references, click to expand
  1. Cross-linking of plasma and cellular fibronectin by plasma transglutaminase.
    Ann N Y Acad Sci. 1978 Jun 20;312:38-42 PMID: 40518
  2. Fibronectins--adhesive glycoproteins of cell surface and blood.
    Nature. 1978 Sep 21;275(5677):179-84 PMID: 357987
  3. An elastin stain.
    Med Lab Technol. 1971 Apr;28(2):148-9 PMID: 4104199
  4. Quantitative immunoelectrophoresis of human serum proteins.
    Clin Sci. 1968 Oct;35(2):403-13 PMID: 5721242
  5. Studies on the character and staining of fibrin.
    J Clin Pathol. 1962 Sep;15:401-13 PMID: 13929601
  6. Distribution of a major connective tissue protein, fibronectin, in normal human tissues.
    J Exp Med. 1978 Apr 1;147(4):1054-64 PMID: 650151
  7. Isolation of a non-collagenous reticulin component and its primary characterization.
    Br J Exp Pathol. 1973 Aug;54(4):449-56 PMID: 4580011
  8. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.
    Anal Biochem. 1966 Apr;15(1):45-52 PMID: 5959431
  9. Interaction of soluble fibroblast surface antigen with fribrinogen and fibrin.
    J Exp Med. 1975 Feb 1;141(2):497-501 PMID: 1113066
  10. Cell surface-associated structural proteins in connective tissue cells.
    Proc Natl Acad Sci U S A. 1977 Jun;74(6):2480-4 PMID: 329287
  11. Immunological characterization of a major transformation-sensitive fibroblast cell surface glycoprotein. Localization, redistribution, and role in cell shape.
    J Cell Biol. 1978 Aug;78(2):520-41 PMID: 357438
  12. Immunochemical quantitation of antigens by single radial immunodiffusion.
    Immunochemistry. 1965 Sep;2(3):235-54 PMID: 4956917
  13. Peroxidase-labeled antibody. A new method of conjugation.
    J Histochem Cytochem. 1974 Dec;22(12):1084-91 PMID: 4443551
  14. Antigenic properties of a non-collagenous reticulin component of normal connective tissue.
    Immunology. 1974 Sep;27(3):469-78 PMID: 4137544
  15. Recongnition by guinea-pig peritoneal exudate cells of conformationally different states of the collagen molecule.
    Immunology. 1976 Feb;30(2):249-59 PMID: 1262053
  16. Preparation and use in immunohistology of antibodies specific for type I and type III collagen and procollagen.
    J Immunol Methods. 1976;12(1-2):117-24 PMID: 792345
  17. Studies on cold insoluble globulin. I Concentrations in citrated plasma in rheumatic disorders.
    Ann Rheum Dis. 1978 Aug;37(4):347-50 PMID: 686867
  18. Epidermal cells adhere preferentially to type IV (basement membrane) collagen.
    J Cell Biol. 1979 Jan;80(1):197-202 PMID: 422650
  19. [Picropolychrome: histological staining technic intended for the study of normal and pathological connective tissue].
    Rev Fr Etud Clin Biol. 1963 Jan;8:88-9 PMID: 13954039
  20. Fibronectin and the pericellular matrix of normal and transformed adherent cells.
    Ann N Y Acad Sci. 1978 Jun 20;312:343-53 PMID: 291368
  21. Affinity of fibronectin to collagens of different genetic types and to fibrinogen.
    J Exp Med. 1978 Jun 1;147(6):1584-95 PMID: 567240
  22. Novel human serum protein from fibroblast plasma membrane.
    Nature. 1974 Apr 26;248(5451):789-91 PMID: 4209027
  23. Histological and immunofluorescent studies on the evolution of the human atheromatous plaque.
    J Atheroscler Res. 1968 Jul-Aug;8(4):599-624 PMID: 4234465
  24. Estimation of eight serum proteins by a gel diffusion precipitin technique.
    J Lab Clin Med. 1962 May;59:859-70 PMID: 13915219
  25. [A micro-method of immuno-electrophoresis].
    Int Arch Allergy Appl Immunol. 1955;7(2):103-10 PMID: 13262900
  26. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.
    J Histochem Cytochem. 1970 May;18(5):315-33 PMID: 4192899
  27. A Simple Method for the Silver Impregnation of Reticulum.
    Am J Pathol. 1936 Jul;12(4):545-552.1 PMID: 19970284
  28. Distribution of fibronectin in human tissues and relationship to other connective tissue components.
    Ann N Y Acad Sci. 1978 Jun 20;312:151-9 PMID: 291359
  29. Identification of the sites in collagen alpha-chains that bind serum anti-gelatin factor (cold-insoluble globulin).
    Biochem J. 1978 Jan 1;169(1):55-9 PMID: 629753
  30. Binding of soluble form of fibroblast surface protein, fibronectin, to collagen.
    Int J Cancer. 1977 Jul 15;20(1):1-5 PMID: 903179
  31. Cold-insoluble globulin (fibronectin), IV[1-35 affinity to soluble collagen of various types.
    Hoppe Seylers Z Physiol Chem. 1978 Feb;359(2):247-50 PMID: 649060
  32. Physiologic role of cold-insoluble globulin in systemic host defense: implications of its characterization as the opsonic alpha 2-surface-binding glycoprotein.
    Ann N Y Acad Sci. 1978 Jun 20;312:43-55 PMID: 91339
Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.40.2.142
Published
1981-04-00
Pages
142-53
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1000696
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.40.2.142 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2