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PMID: 7010607 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cadmium-113 nuclear magnetic resonance studies of bovine insulin: two-zinc insulin hexamer specifically binds calcium.

Science (New York, N.Y.) ·Vol. 212 ·No. 4494 ·1981-05-01 ·Pages 560-2

Sudmeier JL, Bell SJ, Storm MC, Dunn MF

Abstract

By use of cadmium-113 nuclear magnetic resonance spectroscopy, a specific calcium ion binding site has been identified in the bovine two-zinc insulin hexamer. This site is composed of six glutamyl carboxylate groups clustered in the center of the hexamer, and is distinct from the normal zinc ion binding sites.

MeSH Terms

Animals Binding Sites Cadmium Calcium/metabolism Cattle Insulin/metabolism Isotopes Ligands Macromolecular Substances Magnetic Resonance Spectroscopy Protein Conformation Zinc/metabolism

Chemicals

Insulin Isotopes Ligands Macromolecular Substances Cadmium Zinc Calcium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sudmeier J L

Bell S J

Storm M C

Dunn M F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7010607

Published

1981-05-01

Pages

560-2

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCRR NIH HHS · 5S05RR 07010-09 · United States

External Links

PubMed source DOI: 10.1126/science.7010607 View journal details

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Cadmium-113 nuclear magnetic resonance studies of bovine insulin: two-zinc insulin hexamer specifically binds calcium.

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