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PMID: 7010601 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mechanisms of gonadal differentiation.

Science (New York, N.Y.) ·Vol. 211 ·No. 4488 ·1981-03-20 ·Pages 1272-8

Haseltine FP, Ohno S

Abstract

Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.

MeSH Terms

Animals Cattle Disorders of Sex Development Embryonic Induction Female Fertility Freemartinism/genetics Germ Cells/physiology H-Y Antigen/genetics,physiology Humans Male Mammals/genetics Mice Ovary/embryology Rats Sex Chromosomes Sex Determination Analysis Sex Differentiation Testis/embryology,physiology

Chemicals

H-Y Antigen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Haseltine F P

Ohno S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7010601

Published

1981-03-20

Pages

1272-8

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NICHD NIH HHS · 5R01 HD 12289-02 · United States

ADAMHA HHS · R0I AD 00042 · United States

External Links

PubMed source DOI: 10.1126/science.7010601 View journal details

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Mechanisms of gonadal differentiation.

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