Protection of mice against group B Streptococcus type Ia by IgG components of a rabbit antiserum.

Medical microbiology and immunology ·Vol. 169 ·No. 1 ·1980-00-00 ·Pages 9-14

Cleat PH, Coid CR

Abstract

IgG fractions were separated by ion exchange chromatography on DEAE-cellulose from hyperimmune rabbit sera prepared against a group B streptococcus type Ia mouse-virulent strain. 50 microgram IgG in conjunction with ampicillin (200 mg/kg) protected mice more effectively against a lethal challenge than ampicillin (400 mg/kg) alone or ampicillin (200 mg/kg) combined with gentamicin (10 mg/kg), when administered up to 12 h after infection.

MeSH Terms

Ampicillin/therapeutic use Animals Chromatography, DEAE-Cellulose Female Immunoglobulin G/administration & dosage,immunology,isolation & purification Mice Rabbits/immunology Streptococcal Infections/prevention & control Streptococcus agalactiae/immunology

Chemicals

Immunoglobulin G Ampicillin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cleat P H

Coid C R

References (10)

10 references, click to expand

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Pediatr Clin North Am. 1977 Aug;24(3):501-8 PMID: 331208
A simple chromatographic method for preparation of gamma globulin.
Proc Soc Exp Biol Med. 1960 Jan;103:250-2 PMID: 14416397
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J Infect Dis. 1977 Nov;136(5):649-54 PMID: 72125
Antibody levels in mothers colonised with group B streptococci during pregnancy and in their newborn infants, as measured by an enzyme linked immunosorbent assay.
Med Microbiol Immunol. 1980 Feb;168(1):49-53 PMID: 6991897
Blood-transfusion in group-B streptococcal sepsis.
Lancet. 1978 Mar 25;1(8065):636-8 PMID: 76171
Penicillin prophylaxis for neonatal group-B streptococcal infection.
Lancet. 1979 Aug 4;2(8136):246-7 PMID: 89348
ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.
Anal Biochem. 1965 Feb;10:358-61 PMID: 14302464
Mouse protection test for group B Streptococcus type III.
J Infect Dis. 1979 Jul;140(1):81-8 PMID: 88492
Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens.
J Exp Med. 1975 Jul 1;142(1):165-79 PMID: 1097573
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Anal Biochem. 1976 May 7;72:248-54 PMID: 942051

Article Info

Journal

Medical microbiology and immunology

Abbr.

Med Microbiol Immunol

ISSN

0300-8584

DOI

10.1007/BF02123707

Published

1980-00-00

Pages

9-14

Language

English

Region

Germany

NLM ID

0314524

Subset

External Links

PubMed source DOI: 10.1007/BF02123707 View journal details

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Protection of mice against group B Streptococcus type Ia by IgG components of a rabbit antiserum.

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