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PMID: 7007036 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Adh locus in maize for detection of mutagens in the environment.

Environmental health perspectives ·Vol. 37 ·1981-01-00 ·Pages 75-7

Schwartz D

Abstract

The advantages of the maize Adh system for low level mutagenesis studies are discussed. They include high mutation rate and the availability of both a strong selection system for null mutants and a sensitive method for detection of variants. The null selection involves treatment of pollen with allyl alcohol which is converted by the Adh enzyme to the toxic acrylaldehyde. Adh variants can be detected by alteration in affinity for phytic acid as well as thermal stability and electrophoretic mobility.

MeSH Terms
Alcohol Oxidoreductases/genetics Alcohols/metabolism Allyl Compounds/metabolism Environment Ethyl Methanesulfonate/pharmacology Mutagenicity Tests Mutagens Phytic Acid/metabolism Plant Proteins/genetics Selection, Genetic Zea mays/drug effects,genetics
Chemicals
Alcohols Allyl Compounds Mutagens Plant Proteins Phytic Acid Ethyl Methanesulfonate Alcohol Oxidoreductases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Schwartz D
References (5)
5 references, click to expand
  1. Alcohol Dehydrogenase Polymorphism in Maize-simple and Compound Loci.
    Genetics. 1966 Apr;53(4):709-15 PMID: 17248301
  2. The genetic control of alcohol dehydrogenase in maize: gene duplication and repression.
    Proc Natl Acad Sci U S A. 1966 Nov;56(5):1431-6 PMID: 16591390
  3. A molecular basis for heterosis.
    Science. 1969 Oct 31;166(3905):626-7 PMID: 17778204
  4. Mutational study of the alcohol dehydrogenase-1 FCm duplication in maize.
    Biochem Genet. 1979 Dec;17(11-12):1173-80 PMID: 395948
  5. Genetic control of alcohol dehydrogenase--a competition model for regulation of gene action.
    Genetics. 1971 Mar;67(3):411-25 PMID: 5111361
Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.813775
Published
1981-01-00
Pages
75-7
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1568627
Subset
IM
External Links
PubMed source DOI: 10.1289/ehp.813775 PMC Full Text View journal details
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