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PMID: 7003311 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Genetic analysis of resistant mutants to antimitotic benzimidazole compounds in Schizosaccharomyces pombe.

Molecular & general genetics : MGG ·Vol. 180 ·No. 1 ·1980-00-00 ·Pages 231-4

Yamamoto M

Abstract

Mutants resistant to the antimitotic compounds thiabendazole and methyl-2-benzimidazole-carbamate were isolated and analyzed genetically in the fission yeast. Schizosaccharomyces pombe. They comprised three groups in terms of genetic linkage. Mutants in one linkage group (ben1) differed phenotypically from those in the other two (ben2 and ben3). The former were resistant to the compounds at any physiological temperature tested, whereas the latter exhibited temperature dependent resistance. Through tetrad analysis, ben1 was mapped at the rightmost part of chromosome II, and ben2 was mapped near the centromere of the same chromosome. Haploidization experiments revealed the location of ben3 on chromosome II. By analogy with Aspergillus nidulans, it is suggested that one of these ben genes may code for tubulin.

MeSH Terms

Ascomycota/genetics Aspergillus nidulans/genetics Benzimidazoles/pharmacology Carbamates Chromosome Mapping Drug Resistance, Microbial Genes Mutation Schizosaccharomyces/genetics Thiabendazole/pharmacology

Chemicals

Benzimidazoles Carbamates carbendazim Thiabendazole

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Yamamoto M

References (14)

14 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00267375

Published

1980-00-00

Pages

231-4

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00267375

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Genetic analysis of resistant mutants to antimitotic benzimidazole compounds in Schizosaccharomyces pombe.

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