Distribution of fibronectin in normal and diseased human kidneys.

Journal of clinical pathology ·Vol. 33 ·No. 11 ·1980-11-00 ·Pages 1021-8

Dixon AJ, Burns J, Dunnill MS, McGee JO

Abstract

The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material. Biopsies were obtained from normal human kidneys and from patients with a variety of glomerular disorders. In normal glomeruli, fibronectin was present in Bowman's capsule, in the mesangium, and outlining peripheral capillary loops. A significant increase in fibronectin was observed in most types of glomerulopathy with a distribution closely related to the histopathological diagnosis. Fibronectin was diminished or absent in segmental scars, old diabetic nodules, and hyalinised glomeruli.

MeSH Terms

Diabetic Nephropathies/metabolism Fibronectins/analysis Glomerulonephritis/metabolism Humans Immunoenzyme Techniques Kidney Diseases/metabolism Kidney Glomerulus/analysis

Chemicals

Fibronectins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Dixon A J

Burns J

Dunnill M S

McGee J O

References (14)

14 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.33.11.1021

Published

1980-11-00

Pages

1021-8

Language

English

Region

England

NLM ID

0376601

PMCID

PMC1146332

Subset

External Links

PubMed source DOI: 10.1136/jcp.33.11.1021 PMC Full Text View journal details

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Distribution of fibronectin in normal and diseased human kidneys.

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