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PMID: 7002912 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Suppression of polarity in the gal operon by ultraviolet irradiation.

Journal of bacteriology ·Vol. 144 ·No. 3 ·1980-12-00 ·Pages 1205-7

Fassler JS, Tessman I

Abstract

The polarity of nonsense mutations in the galE gene of Escherichia coli can be suppressed by rho mutations (O. Reyes et al., J. Bacteriol. 126:1108-1112, 1976). We show here that this polarity can also be suppressed by ultraviolet irradiation. The effect is analogous to that already observed for polar nonsense mutations in phi X174 and S13 and suggests that ultraviolet irradiation suppression of polarity may be a general phenomenon.

MeSH Terms

Escherichia coli/enzymology,genetics Galactokinase/genetics Galactose/metabolism Gene Expression/radiation effects Mutation Operon Protein Biosynthesis/radiation effects Suppression, Genetic UTP-Hexose-1-Phosphate Uridylyltransferase/genetics Ultraviolet Rays

Chemicals

Galactokinase UTP-Hexose-1-Phosphate Uridylyltransferase Galactose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fassler J S

Tessman I

References (15)

15 references, click to expand

Effects of ultraviolet radiation on macromolecular synthesis in Escherichia coli.
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RNA synthesis in Escherichia coli after irradiation with ultraviolet light.
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Transcription on irradiated DNA.
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The galactose operon of E. coli K-12. I. Structural and pleiotropic mutations of the operon.
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Integrative and excisive recombination by bacteriophage lambda: evidence for an excision-specific recombination protein.
J Mol Biol. 1970 Feb 14;47(3):575-83 PMID: 4907273
In vitro transcription of the gal operon requires cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein.
J Biol Chem. 1971 Aug 10;246(15):4671-8 PMID: 4327324
Potassium transport loci in Escherichia coli K-12.
J Bacteriol. 1971 Nov;108(2):639-44 PMID: 4942756
Isolation of plaque-forming, galactose-transducing strains of phage lambda.
Genetics. 1972 Jun;71(2):189-206 PMID: 4558323
Effect of Rho on transcription of bacterial operons.
Nat New Biol. 1973 Feb 28;241(113):260-4 PMID: 4348358
Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2534-8 PMID: 4601822
Suppression of polarity of insertion mutations in the gal operon and N mutations in bacteriophage lambda.
J Bacteriol. 1976 Jun;126(3):1108-12 PMID: 181361
Expression of a bacterial gene turned on by a potent carcinogen.
Mutat Res. 1978 Apr;50(1):29-35 PMID: 205783
Suppression of polar effects of nonsense mutations by ultraviolet irradiation.
J Bacteriol. 1979 Apr;138(1):122-5 PMID: 438127
[REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF THE ENZYMES OF GALACTOSE METABOLISM IN ESCHERICHIA COLI K 12. I. THE INDUCED BIOSYNTHESIS OF GALACTOKINASE AND THE SIMULTANEOUS INDUCTION OF THE ENZYMATIC SEQUENCE].
J Mol Biol. 1963 Aug;7:164-82 PMID: 14062650
[REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF THE ENZYMES OF GALACTOSE METABOLISM IN ESCHERICHIA COLI K 12. II. THE GENETIC DETERMINISM OF THE REGULATION].
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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.144.3.1205-1207.1980

Published

1980-12-00

Pages

1205-7

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC294795

Subset

Grants

NCI NIH HHS · CA-22239 · United States

NIGMS NIH HHS · GM-7076 · United States

External Links

PubMed source DOI: 10.1128/jb.144.3.1205-1207.1980 PMC Full Text View journal details

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Suppression of polarity in the gal operon by ultraviolet irradiation.

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