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PMID: 6998708 Published · ppublish English Comparative Study Journal Article

Time course of blood pressure, pulse rate, plasma renin and metoprolol during treatment of hypertensive patients.

European journal of clinical pharmacology ·Vol. 17 ·No. 5 ·1980-05-00 ·Pages 321-8

Haglund K, Collste P

Abstract

Eleven patients were treated for essential hypertension with metoprolol (Selokén) for more than three months. The time course of changes in blood pressure, pulse rate and plasma renin activity was studied during treatment with an oral maintenance dose of 100 mg twice daily. Significant decreases in pulse rate, diastolic blood pressure and plasma renin activity were observed even after the first dose. The plasma concentration of metoprolol reached equilibrium after the second dose. After the third dose there was no further significant change in blood pressure. There was a significant correlation (p < 0.001) between the initial (after three doses) and final (after > 90 days) effect of metoprolol on blood pressure (r = 0.86 and 0.91 for systolic and diastolic blood pressure change, respectively).

MeSH Terms
Adult Blood Pressure/drug effects Female Heart Rate/drug effects Humans Hypertension/blood,drug therapy,physiopathology Male Metoprolol/blood,therapeutic use Middle Aged Propanolamines/therapeutic use Renin/blood Time Factors
Chemicals
Propanolamines Renin Metoprolol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Haglund K
Collste P
References (29)
29 references, click to expand
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Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
DOI
10.1007/BF00558443
Published
1980-05-00
Pages
321-8
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00558443 View journal details
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