Aplastic anemia: recent advances in pathogenesis and treatment.

The Medical clinics of North America ·Vol. 64 ·No. 4 ·1980-07-00 ·Pages 607-29

Silver BJ, Zuckerman KS

Abstract

Successful bone marrow transplantation and bone marrow culturing techniques have generated a large body of research into the pathogenesis and treatment of aplastic anemia. Most prominent has been the emphasis on autoimmune mechanisms. Several etiologic types and diagnostic criteria are discussed, the evidence supporting immune and other mechanisms of pathogenesis is examined, and results of current therapeutic trials are addressed.

MeSH Terms

Adrenal Cortex Hormones/therapeutic use Androgens/therapeutic use Anemia, Aplastic/diagnosis,etiology,therapy Animals Antilymphocyte Serum/therapeutic use Blood Transfusion Bone Marrow Transplantation Cell Differentiation Cytotoxicity, Immunologic Hematopoietic Stem Cells/cytology,immunology Humans Lithium/therapeutic use Mice Rats T-Lymphocytes/immunology

Chemicals

Adrenal Cortex Hormones Androgens Antilymphocyte Serum Lithium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Silver B J

Zuckerman K S

Article Info

Journal

The Medical clinics of North America

Abbr.

Med Clin North Am

ISSN

0025-7125

DOI

10.1016/s0025-7125(16)31584-x

Published

1980-07-00

Pages

607-29

Language

English

Region

United States

NLM ID

2985236R

Subset

External Links

PubMed source DOI: 10.1016/s0025-7125(16)31584-x View journal details

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Aplastic anemia: recent advances in pathogenesis and treatment.

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