Home LiteratureArticle Details
PMID: 6988200 Published · ppublish English Journal Article Review

Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections.

Drugs ·Vol. 19 ·No. 1 ·1980-01-00 ·Pages 7-30

Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS

Abstract

Miconazole is an imidazole antifungal drug which has recently become available for systemic use. Its antifungal activity has been well studied and it is active in vitro against a wide range of fungi. Published and unpublished reports of the use of miconazole in conditions such as systemic or mucocutaneous candidosis, coccidioidomycosis, fungal meningitis, and paracoccidioidomycosis (which seems especially responsive) have often been encouraging, particularly in view of the serious, refractory nature of the conditions treated, but in most areas of use experience is limited. There are few effective drugs available for treating most systemic fungal infections, and if further studies confirm the encouraging results often seen to date, miconazole will be an important addition to the limited choices available for such conditions.

MeSH Terms
Animals Humans Imidazoles/therapeutic use Intestinal Absorption Kidney Diseases/metabolism Kinetics Miconazole/administration & dosage,adverse effects,metabolism,therapeutic use,toxicity Mycoses/drug therapy,prevention & control
Chemicals
Imidazoles Miconazole
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Heel R C
Brogden R N
Pakes G E
Speight T M
Avery G S
References (80)
80 references, click to expand
  1. Antimicrobial activity of econazole and miconazole in vitro and in experimental candidiasis and aspergillosis.
    Chemotherapy. 1976;22(3-4):211-20 PMID: 817875
  2. Side effects of miconazole for systemic mycoses.
    N Engl J Med. 1977 Oct 6;297(14):786-7 PMID: 895811
  3. Round table discussion: miconazole(1)tolerance and toxicity (2) route of administration (3) indications for use.
    Proc R Soc Med. 1977;70(Suppl 1):51-4 PMID: 20919309
  4. Miconazole treatment of relapsed pulmonary blastomycosis.
    Am Rev Respir Dis. 1978 Aug;118(2):403-8 PMID: 697188
  5. Miconazole in the treatment of systemic fungal infections.
    Am Rev Respir Dis. 1977 Nov;116(5):801-6 PMID: 921060
  6. Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans.
    Chem Biol Interact. 1978 Apr;21(1):59-78 PMID: 352553
  7. Unusual serum lipoprotein abnormality induced by the vehicle of miconazole.
    N Engl J Med. 1977 Mar 3;296(9):497-9 PMID: 834227
  8. Use of miconazole for prevention of opportunistic fungal infection during treatment of haematological malignancies.
    Proc R Soc Med. 1977;70 Suppl 1:32-4 PMID: 122645
  9. Miconazole for treatment of disseminated coccidioidomycosis. Unfavorable experience.
    Chest. 1978 Jun;73(6):825-31 PMID: 657856
  10. Successful treatment of systemic cryptococcosis with miconazole.
    Br Med J. 1979 Jul 14;2(6182):100-1 PMID: 466288
  11. Miconazole in the treatment of chronic mucocutaneous candidiasis: a preliminary report.
    J Pediatr. 1977 Nov;91(5):815-9 PMID: 909025
  12. Disseminated candidiasis in a patient with acute leukemia. Successful treatment with miconazole.
    JAMA. 1977 Mar 14;237(11):1124-5 PMID: 264981
  13. Results of miconazole therapy in twenty-eight patients with paracoccidioidomycosis (South American blastomycosis).
    Proc R Soc Med. 1977;70 Suppl 1:24-8 PMID: 122643
  14. Pulmonary and cerebral mycetoma caused by Curvularia pallescens.
    J Pediatr. 1977 Oct;91(4):603-5 PMID: 561837
  15. Therapeutic failures with miconazole.
    Antimicrob Agents Chemother. 1978 Jun;13(6):965-8 PMID: 354523
  16. Successful treatment of cryptococcal meningitis with intraventricular miconazole.
    Arch Intern Med. 1978 May;138(5):814-6 PMID: 646546
  17. The ultrastructure of Candida albicans after in vitro treatment with miconazole.
    Sabouraudia. 1974 Nov;12(3):341-51 PMID: 4610826
  18. Miconazole carrier solution, hyperlipidemia and hematologie problems.
    N Engl J Med. 1977 Jun 23;296(25):1479 PMID: 865521
  19. Deep infections from Petriellidium boydii treated with miconazole.
    JAMA. 1979 Jan 19;241(3):272-3 PMID: 758531
  20. Miconazole, a broad-spectrum antimycotic agent with antibacterial activity.
    Chemotherapy. 1972;17(6):392-404 PMID: 4563141
  21. A case of chronic oropharyngo-esophageal candidiasis with immunological deficiency: successful treatment with miconazole.
    Gastroenterology. 1977 Mar;72(3):536-40 PMID: 832803
  22. Mechanism of action of miconazole: labilization of rat liver lysosomes in vitro by miconazole.
    Antimicrob Agents Chemother. 1976 Jun;9(6):903-7 PMID: 7188
  23. Letter: Antagonism between miconazole and amphotericin B.
    Lancet. 1976 Aug 7;2(7980):318 PMID: 59892
  24. Synergistic action of miconazole and atromid-S on Candida albicans.
    Mil Med. 1979 Jul;144(7):474-5 PMID: 116154
  25. Miconazole therapy for systemic candidiasis in a conjoined (Siamese) twin and a premature newborn.
    Am J Surg. 1979 Nov;138(5):688-91 PMID: 386810
  26. Paracoccidioidomycosis (South American blastomycosis): treatment with miconazole.
    Am J Trop Med Hyg. 1978 Jul;27(4):801-7 PMID: 686247
  27. Biochemical effects of miconazole on fungi. I. Effects on the uptake and or utilization of purines, pyrimidines, nucleosides, amino acids and glucose by Candida albicans.
    Biochem Pharmacol. 1974 Feb 15;23(4):887-99 PMID: 4596244
  28. In vitro comparison of the antifungal activities of R34,000, miconazole and amphotericin B.
    Chemotherapy. 1978;24(6):364-7 PMID: 699677
  29. The effects of miconazole on the ultrastructure of Candida albicans.
    Proc R Soc Med. 1977;70 Suppl 1:9-12 PMID: 233843
  30. Miconazole treatment of candida sepsis in aminophenazone induced agranulocytosis.
    Acta Paediatr Belg. 1978 Jul-Sep;31(3):151-3 PMID: 707093
  31. Mucoid impaction of the bronchi apparently responding to antifungal therapy.
    Chest. 1979 Jul;76(1):116 PMID: 446162
  32. Combined intravenous miconazole and intrathecal amphotericin B for treatment of disseminated coccidioidomycosis.
    Chest. 1979 Aug;76(2):235-6 PMID: 582301
  33. Petriellidium boydii (Allescheria boydii) sphenoidal sinusitis.
    JAMA. 1978 Jun 2;239(22):2368-9 PMID: 642177
  34. Intravenous miconazole therapy of mycotic infections.
    Arch Intern Med. 1979 Jul;139(7):784-6 PMID: 454066
  35. Letter: Chemotherapy of candidiasis.
    Br Med J. 1974 Jan 12;1(5897):78 PMID: 4812399
  36. Miconazole: a review of its antifungal activity and therapeutic efficacy.
    Drugs. 1975;9(6):406-23 PMID: 1149649
  37. Antagonistic action of lipid components of membranes from Candida albicans and various other lipids on two imidazole antimycotics, clotrimazole and miconazole.
    Antimicrob Agents Chemother. 1977 Jul;12(1):16-25 PMID: 329757
  38. [Renal and urothelial candidiasis].
    Acta Urol Belg. 1974 Oct;42(4):452-71 PMID: 4467712
  39. [Successful treatment of candida sepsis with miconazole (author's transl)].
    Dtsch Med Wochenschr. 1974 Dec 6;99(49):2512, 2515-9 PMID: 4434849
  40. Interference of granulocyte function by the vehicle of miconazole.
    Antimicrob Agents Chemother. 1978 Mar;13(3):548-51 PMID: 263892
  41. Intravenous miconazole in the treatment of chronic esophageal candidiasis.
    Gastroenterology. 1977 Feb;72(2):316-8 PMID: 830582
  42. [Possibly cardiotoxic action of miconazol injection fluid].
    Ned Tijdschr Geneeskd. 1975 Oct 4;119(40):1549-51 PMID: 52126
  43. Treatment of fungal infections with miconazole.
    Proc R Soc Med. 1977;70 Suppl 1:40-2 PMID: 122648
  44. Treatment of South American blastomycosis (paracoccidioidomycosis) with miconazole by the oral route: an on-going study.
    Proc R Soc Med. 1977;70 Suppl 1:35-9 PMID: 122646
  45. Eruptive xanthomas associated with intravenous miconazole therapy.
    Arch Dermatol. 1978 Oct;114(10):1544-5 PMID: 718197
  46. Miconazole therapy for fungal meningitis.
    Arch Neurol. 1978 Jul;35(7):443-7 PMID: 580889
  47. Susceptibility of Canadida albicans to miconazole.
    Antimicrob Agents Chemother. 1978 Jun;13(6):1040-1 PMID: 354517
  48. Intravenous and intrathecal miconazole therapy for systemic mycoses.
    West J Med. 1977 Jan;126(1):5-13 PMID: 576177
  49. Miconazole in the treatment of candidiasis of the digestive tract.
    Acta Derm Venereol. 1976;56(4):303-6 PMID: 60027
  50. [Therapy of systemic candidiasis using miconazol].
    Med Welt. 1974 Mar 8;25(10):428-9 PMID: 4820433
  51. Miconazole in systemic candidiasis.
    Proc R Soc Med. 1977;70 Suppl 1:18-9 PMID: 122640
  52. Miconazole-resistant Candida.
    Lancet. 1978 Jan 7;1(8054):50-1 PMID: 74535
  53. Growth inhibition of Naegleria fowleri by tetracycline, rifamycin, and miconazole.
    Lancet. 1977 Oct 22;2(8043):876 PMID: 72223
  54. Visceral fungal infections due to Petriellidium boydii (allescheria boydii). In vitro drug sensitivity studies.
    Am J Med. 1976 Nov;61(5):632-40 PMID: 984066
  55. Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.
    Antimicrob Agents Chemother. 1976 Oct;10(4):721-8 PMID: 984806
  56. Miconazole in coccidiodomycosis. II. Therapeutic and pharmacologic studies in man.
    Am J Med. 1976 Feb;60(2):191-202 PMID: 766623
  57. Studies on the mechanism of action of miconazole- II. Interaction of miconazole with mammalian erythrocytes.
    Biochem Pharmacol. 1976 May 15;25(10):1145-50 PMID: 938538
  58. In vitro studies with miconazole and miconazole nitrate.
    J Antimicrob Chemother. 1977 Mar;3(2):147-52 PMID: 863803
  59. A case of candida albicans endocarditis 3 years after an aortic valve replacement. Successful combined medical and surgical therapy.
    J Cardiovasc Surg (Torino). 1977 Jul-Aug;18(4):391-6 PMID: 142090
  60. Allescheria boydii osteomyelitis following multiple steroid injections and surgery.
    Clin Orthop Relat Res. 1977 Jul-Aug;(126):232-4 PMID: 598124
  61. Treatment of disseminated coccidioidomycosis with miconazole.
    West J Med. 1976 Jan;124(1):61-4 PMID: 1251606
  62. Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.
    Antimicrob Agents Chemother. 1974 Apr;5(4):420-5 PMID: 15825399
  63. Miconazole treatment in candidal oesophagitis.
    Proc R Soc Med. 1977;70 Suppl 1:47-50 PMID: 122650
  64. Miconazole in coccidioidomycosis. I. Assays of activity in mice and in vitro.
    J Infect Dis. 1975 Oct;132(4):407-14 PMID: 1185010
  65. Evaluation of miconazole therapy in experimental disseminated candidiasis in laboratory rats.
    Antimicrob Agents Chemother. 1978 Feb;13(2):321-5 PMID: 646350
  66. Systemic miconazole treatment of a patient with chronic granulomatous mucocutaneous candidiasis.
    Acta Derm Venereol. 1978;58(5):455-9 PMID: 82358
  67. Miconazole in systemic mycosis.
    Proc R Soc Med. 1977;70 Suppl 1:43-6 PMID: 122649
  68. Experimental in vitro and in vivo comparison of modern antimycotics.
    Curr Med Res Opin. 1977-1978;5(4):315-27 PMID: 630908
  69. Protection by unsaturated lecithin against the imidazole antimycotics, clotrimazole and miconazole.
    Antimicrob Agents Chemother. 1978 Mar;13(3):423-6 PMID: 400822
  70. Treatment of experimental murine cryptococcosis: a comparison of miconazole and amphotericin B.
    Antimicrob Agents Chemother. 1978 Feb;13(2):277-83 PMID: 348099
  71. R34000, a dioxolane imidazole in the therapy for experimental coccidioidomycosis. Comparison with miconazole and econazole.
    Chest. 1976 Dec;70(6):755-9 PMID: 1001052
  72. Inhibitory effect of miconazole on mitogen-induced lymphocyte proliferative responses.
    Br Med J. 1978 Jan 21;1(6106):149 PMID: 620230
  73. Pulmonary sporotrichosis: Treatment with miconazole.
    Am Rev Respir Dis. 1976 Aug;114(2):403-6 PMID: 973727
  74. Hyperlipidemia related to miconazole therapy.
    Ann Intern Med. 1979 Sep;91(3):491-2 PMID: 475186
  75. Miconazole in systemic candidosis.
    Proc R Soc Med. 1977;70 Suppl 1:20-3 PMID: 122642
  76. Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study.
    Acta Med Scand. 1978;204(1-2):123-8 PMID: 356523
  77. Treatment of fungal meningitis with miconazole.
    Arch Intern Med. 1977 Sep;137(9):1180-5 PMID: 901086
  78. Reversible thrombocytosis and anemia due to miconazole therapy.
    Antimicrob Agents Chemother. 1976 Sep;10(3):447-9 PMID: 984785
  79. Miconazole therapy for coccidioidomycosis.
    JAMA. 1974 Nov 25;230(8):1153-7 PMID: 4479523
  80. Cytochemical and biochemical studies of yeasts after in vitro exposure to miconazole.
    Antimicrob Agents Chemother. 1977 Mar;11(3):500-13 PMID: 193437
Article Info
Journal
Drugs
Abbr.
Drugs
ISSN
0012-6667
DOI
10.2165/00003495-198019010-00002
Published
1980-01-00
Pages
7-30
Language
English
Region
New Zealand
NLM ID
7600076
Subset
IM
External Links
PubMed source DOI: 10.2165/00003495-198019010-00002 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2