Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia.

Bulletin of the World Health Organization ·Vol. 60 ·No. 3 ·1982-00-00 ·Pages 389-94

Kazár J, Brezina R, Palanová A, Tvrdá B, Schramek S

Abstract

An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.

MeSH Terms

Animals Antibodies, Bacterial/biosynthesis Bacterial Vaccines/immunology,therapeutic use Coxiella/immunology Guinea Pigs Humans Q Fever/immunology,prevention & control Skin Tests

Chemicals

Antibodies, Bacterial Bacterial Vaccines

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kazár J

Brezina R

Palanová A

Tvrdá B

Schramek S

References (16)

16 references, click to expand

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Article Info

Journal

Bulletin of the World Health Organization

Abbr.

Bull World Health Organ

ISSN

0042-9686

Published

1982-00-00

Pages

389-94

Language

English

Region

Switzerland

NLM ID

7507052

PMCID

PMC2536007

Subset

External Links

PubMed source PMC Full Text View journal details

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Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia.

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