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PMID: 6978217 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Schistosoma mansoni: autoantibodies and polyclonal B cell activation in infected mice.

Clinical and experimental immunology ·Vol. 46 ·No. 1 ·1981-10-00 ·Pages 89-97

Fischer E, Camus D, Santoro F, Capron A

Abstract

The appearance of autoantibodies was investigated during the course of Schistosoma mansoni infection in C57Bl/6 mice. Anti-liver autoantibodies or lymphocyte-reactive alloantibodies were detected respectively without cell-mediated immunity against liver antigen or lymphocytotoxic activity. Anti-liver, anti-DNA, anti-Ig and anti-lymphocyte antibodies were shown 6-7 weeks after the beginning of the infection concomitantly with the increase of immunoglobulin levels and circulating immune complexes. At this period, the antibody response to polyvinylpyrrolidone (PVP) was increased and the injection of spleen cells from day-45-infected mice to uninfected recipients increased the anti-PVP antibody response. Conversely, the injection of spleen cells from uninfected to infected mice did not modify the anti-PVP Ab response. After 6 weeks of infection, the basal thymidine incorporation of spleen cells was increased contrasting with the marked inhibition of spleen cell response to PHA. The present data are consistent with the induction of a polyclonal non-specific B cell activation by S. mansoni.

MeSH Terms
Animals Antibody Formation Antigen-Antibody Complex/analysis Antilymphocyte Serum/immunology Autoantibodies/biosynthesis B-Lymphocytes/immunology Liver/immunology Lymphocyte Activation Mice Mice, Inbred C57BL Povidone/immunology Schistosoma mansoni/immunology Schistosomiasis/immunology Spleen/immunology
Chemicals
Antigen-Antibody Complex Antilymphocyte Serum Autoantibodies Povidone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fischer E
Camus D
Santoro F
Capron A
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43 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1981-10-00
Pages
89-97
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1536336
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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