The characterization of the delayed-type hypersensitivity reaction to H-Y antigens.
We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity was somewhat slighter. B10.A(2R), B10.D2 and BALB/c female mice could not respond to immunization with syngeneic male cells. The response was male-antigen specific and transferable by thymus-derived cells. Moreover, suggestive evidence of representation of H-Y was obtained, based on the ability of responder strains immunized with syngeneic cells to react to nonresponder male cells upon challenge.
10 references, click to expand
-
Male-specific graft rejection and the H-2 locus.Transplantation. 1971 Dec;12(6):527-31 PMID: 4941059
-
Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.J Exp Med. 1978 Mar 1;147(3):758-67 PMID: 416165
-
Delayed-type hypersensitivity responses to H-Y: characterization and mapping of Ir genes.Immunogenetics. 1980;11(3):255-66 PMID: 6793506
-
A gene governing the female immune response to the male antigen in mice.Transplantation. 1971 Apr;11(4):404-7 PMID: 4934351
-
Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.J Exp Med. 1978 Mar 1;147(3):768-75 PMID: 416166
-
Genetic control of the immune response in mice. 3. An association between H-2 type and reaction to H-Y.J Immunol. 1971 Mar;106(3):875-6 PMID: 4926269
-
Mechanisms of regulation of cell-mediated immune responses. I. Effect of the route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picryl chloride.J Immunol. 1978 May;120(5):1604-11 PMID: 659864
-
Delayed-type hypersensitivity to allogeneic cells in mice. III. Sensitivity to cell-surface antigens coded by the major histocompatibility complex and by other genes.J Exp Med. 1979 Oct 1;150(4):965-76 PMID: 315988
-
Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.Proc Natl Acad Sci U S A. 1978 May;75(5):2439-42 PMID: 307765
-
The relationship between tumor antigens and alloantigens: cross-reactivity due to differential context of T cell antigen recognition.J Immunol. 1980 Aug;125(2):738-48 PMID: 6967088
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
