Properties of a glycopeptide isolated from human Tamm-Horsfall glycoprotein. Interaction with leucoagglutinin and anti-(human Tamm-Horsfall glycoprotein) antibodies.

The Biochemical journal ·Vol. 187 ·No. 2 ·1980-05-01 ·Pages 525-8

Abbondanza A, Franceschi C, Licastro F, Serafini-Cessi F

Abstract

A sialylated glycopeptide isolated after Pronase digestion of human Tamm-Horsfall glycoprotein behaves as a powerful monovalent hapten in the precipitin reaction between human Tamm-Horsfall glycoprotein and leucoagglutinin, but fails to inhibit the interaction of the glycoprotein with rabbit anti-(human Tamm-Horsfall glycoprotein) antibodies. The glycopeptide is much less active than the intact glycoprotein as an inhibitor of lymphocyte transformation induced by leucoagglutinin.

MeSH Terms

Agglutinins Antibodies, Anti-Idiotypic Glycopeptides/immunology,isolation & purification,pharmacology Glycoproteins/urine Humans Leukocytes Lymphocyte Activation/drug effects Mucoproteins/pharmacology Proteins Uromodulin

Chemicals

Agglutinins Antibodies, Anti-Idiotypic Glycopeptides Glycoproteins Mucoproteins Proteins UMOD protein, human Uromodulin leukoagglutinins, leukocytes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Abbondanza A

Franceschi C

Licastro F

Serafini-Cessi F

References (17)

17 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1870525

Published

1980-05-01

Pages

525-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1161820

Subset

External Links

PubMed source DOI: 10.1042/bj1870525 PMC Full Text View journal details

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Properties of a glycopeptide isolated from human Tamm-Horsfall glycoprotein. Interaction with leucoagglutinin and anti-(human Tamm-Horsfall glycoprotein) antibodies.

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