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PMID: 6965308 Published · ppublish English Journal Article

Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.

The Journal of experimental medicine ·Vol. 151 ·No. 1 ·1980-01-01 ·Pages 246-51

Smith FI, Miller JF

Abstract

The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.

MeSH Terms
Animals Bone Marrow Cells Chimera Female Histocompatibility Antigens Hybridization, Genetic Immunosuppression Therapy Lymph Nodes/cytology,transplantation Mice T-Lymphocytes/immunology Thymectomy Thymus Gland/cytology
Chemicals
Histocompatibility Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Smith F I
Miller J F
References (18)
18 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.151.1.246
Published
1980-01-01
Pages
246-51
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185764
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.151.1.246 PMC Full Text View journal details
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