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PMID: 6964395 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nonrandom distribution of repeated DNA sequences with respect to supercoiled loops and the nuclear matrix.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 19 ·1982-10-00 ·Pages 5911-5

Small D, Nelkin B, Vogelstein B

Abstract

The DNA in a eukaryotic nucleus is arranged into a series of supercoiled loops that are anchored at their bases to the nuclear matrix. We have analyzed the DNA sequences that are closest to the matrix attachment points for their relative content of specific repeated sequences. Sequences were enriched (mouse satellite, human Alu family) or depleted (mouse EcoRI repeat, monkey alpha component), depending on the specific sequence and species examined. These results can be understood in terms of a nonrandom arrangement of DNA sequences with respect to nuclear DNA loops.

MeSH Terms
Animals Cell Line Cell Nucleus/analysis,ultrastructure Chlorocebus aethiops DNA/genetics DNA, Satellite/genetics DNA, Superhelical/genetics Humans Mice Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
DNA, Satellite DNA, Superhelical DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Small D
Nelkin B
Vogelstein B
References (40)
40 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.19.5911
Published
1982-10-00
Pages
5911-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347020
Subset
IM
Grants
NCI NIH HHS · CA-09243 · United States
NIGMS NIH HHS · GM-07309 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.19.5911 PMC Full Text View journal details
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