A neural cell adhesion molecule from human brain.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 20 ·1982-10-00 ·Pages 6380-4

McClain DA, Edelman GM

Abstract

We have used a crossreactive monoclonal antibody against a mouse neural cell adhesion molecule (N-CAM) to characterize and purify an antigen from embryonic and neonatal human brain. This antigen was identified as human N-CAM according to several criteria, including molecular weight, sialic acid content, amino acid composition, analysis of peptide fragments, reactivity with a variety of anti-CAM antibodies, and activity of the antigen in assays of cell and membrane vesicle aggregation. The findings make feasible an exploration of the possible role of N-CAM in various neurological disorders.

MeSH Terms

Amino Acids/analysis Antibodies, Monoclonal Brain Chemistry Cell Adhesion Cell Aggregation Humans Nerve Tissue Proteins/immunology,isolation & purification Neurons/analysis,cytology

Chemicals

Amino Acids Antibodies, Monoclonal Nerve Tissue Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

McClain D A

Edelman G M

References (11)

11 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.79.20.6380

Published

1982-10-00

Pages

6380-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC347125

Subset

External Links

PubMed source DOI: 10.1073/pnas.79.20.6380 PMC Full Text View journal details

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A neural cell adhesion molecule from human brain.

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