Effects of intra-arterial prostaglandin E2 on gallbladder fluid transport, motility, and hepatic bile in the cat.

The effects of intra-arterial infusion of prostaglandin E2 on gallbladder concentrating function, motility, and hepatic bile flow were studied simultaneously in the anesthetized cat by means of a perfusion technique. Prostaglandin E2 reversibly inhibited gallbladder net fluid absorption and in some cases reversed the direction of transport to a net fluid secretion. A contraction of the gallbladder and an increased flow of hepatic bile were seen during prostaglandin infusion. The results are discussed in relation to the role of prostaglandins in the pathophysiology of cholecystitis.