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PMID: 6950412 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 12 ·1981-12-00 ·Pages 7742-4

Sher JH, Stracher A, Shafiq SA, Hardy-Stashin J

Abstract

Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.

MeSH Terms
Animals Leupeptins/administration & dosage,therapeutic use Mice Muscular Dystrophy, Animal/drug therapy,genetics,pathology Oligopeptides/therapeutic use Time Factors
Chemicals
Leupeptins Oligopeptides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sher J H
Stracher A
Shafiq S A
Hardy-Stashin J
References (20)
20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.12.7742
Published
1981-12-00
Pages
7742-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC349346
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.12.7742 PMC Full Text View journal details
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