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PMID: 694732 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Isolation of amiloride-resistant clones from dog kidney epithelial cells.

Somatic cell genetics ·Vol. 4 ·No. 5 ·1978-09-00 ·Pages 609-16

Taub M

Abstract

The diuretic drug amiloride has been used to select variants from the dog kidney cell line MDCK which are partially resistant to killing by the drug. Evidence is presented suggesting that resistance to killing by amiloride is conferred by decreased uptake of amiloride, which reduces the intracellular drug concentration below the toxic level.

MeSH Terms

Amiloride/pharmacology Biological Transport/drug effects Cell Communication Cell Line Cell Survival/drug effects Dose-Response Relationship, Drug Drug Resistance Epithelium/drug effects Mitochondria/drug effects Mutation Pyrazines/pharmacology Sodium/metabolism

Chemicals

Pyrazines Amiloride Sodium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Taub M

Article Info

Journal

Somatic cell genetics

Abbr.

Somatic Cell Genet

ISSN

0098-0366

DOI

10.1007/BF01542930

Published

1978-09-00

Pages

609-16

Language

English

Region

United States

NLM ID

7506054

Subset

External Links

PubMed source DOI: 10.1007/BF01542930

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Isolation of amiloride-resistant clones from dog kidney epithelial cells.

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