Progressive chromosome changes associated with different sites of one ovarian carcinoma.

Karyotype analyses were done on cells from the primary and metastatic sites, as well as on the ascitic fluid, from 1 patient with serous carcinoma of the ovary. An increase in the proportion of near-tetraploid cells occurred in the following order: cells from the primary site less than cells from the metastatic site less than cells from ascitic fluid. In addition, two new marker chromosomes appeared among the polyploid cells of ascitic fluid.