Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene.

Nature ·Vol. 275 ·No. 5680 ·1978-10-12 ·Pages 510-3

Catterall JF, O'Malley BW, Robertson MA, Staden R, Tanaka Y, Brownlee GG

Abstract

A short partial sequence homology is present at all intron-exon junctions, or splice points, in the chick ovalbumin gene; it is probably a signal for a splicing enzyme. The significance of the junction sequences for splicing is discussed. We find no evidence of strong Watson-Crick base pairing between adjacent junctions.

MeSH Terms

Animals Base Sequence Chickens Hydrogen Bonding Nucleic Acid Conformation Nucleic Acid Precursors/genetics Ovalbumin/genetics RNA Ligase (ATP)/metabolism RNA, Heterogeneous Nuclear/genetics RNA, Messenger/genetics Substrate Specificity

Chemicals

Nucleic Acid Precursors RNA, Heterogeneous Nuclear RNA, Messenger Ovalbumin RNA Ligase (ATP)

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Catterall J F

O'Malley B W

Robertson M A

Staden R

Tanaka Y

Brownlee G G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/275510a0

Published

1978-10-12

Pages

510-3

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/275510a0 View journal details

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Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene.

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