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PMID: 6916710 Published · ppublish English Journal Article

The activation of the alternative pathway C3 convertase by human plasma kallikrein.

Immunology ·Vol. 45 ·No. 3 ·1982-03-00 ·Pages 587-95

DiScipio RG

Abstract

Human plasma kallikrein can replace factor D for the activation of the alternative pathway C3 convertase of human complement. The factor B cleavage patterns by factor D and kallikrein are indistinguishable. The ability of kallikrein to cleave factor B is influenced by the magnesium ion concentration and the C3b concentration. Factor D is about ten-fold more effective on a molar basis, for the alternative pathway C3 convertase activation than is kallikrein. The physiological role of the action of kallikrein on the alternative pathway C3 convertase is discussed.

MeSH Terms
Centrifugation, Density Gradient Chromatography, Gel Complement Activating Enzymes/metabolism Complement Activation/drug effects Complement C3-C5 Convertases/metabolism Complement Factor B/metabolism Complement Factor D/pharmacology Complement Pathway, Alternative/drug effects Electrophoresis, Polyacrylamide Gel Enzyme Activation/drug effects Humans Kallikreins/antagonists & inhibitors,blood,pharmacology
Chemicals
Complement Activating Enzymes Complement C3-C5 Convertases Kallikreins CFD protein, human Complement Factor D Complement Factor B
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
DiScipio R G
References (36)
36 references, click to expand
  1. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.
    J Biol Chem. 1969 Aug 25;244(16):4406-12 PMID: 5806584
  2. Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.
    J Biol Chem. 1970 Jun;245(12):3059-65 PMID: 5432796
  3. C3 proactivator convertase and its mode of action.
    J Exp Med. 1972 Apr 1;135(4):1003-8 PMID: 4111773
  4. Prekallikrein deficiency in man.
    J Exp Med. 1973 Dec 1;138(6):1345-55 PMID: 4762550
  5. The reaction of zymosan with the properdin system: isolation of purified factor D from guinea pig serum and study of its reaction characteristics.
    J Immunol. 1974 May;112(5):1845-54 PMID: 4818461
  6. Formation of the C3-cleaving properdin enzyme on zymosan. Demonstration that factor D is replaceable by proteolytic enzymes.
    J Immunol. 1974 Dec;113(6):1735-43 PMID: 4279261
  7. Factor D in the alternate pathway of complement activation: purification, physicochemical characterization and functional role.
    Immunochemistry. 1974 Sep;11(9):527-32 PMID: 4459260
  8. A simple two-step isolation procedure for human and bovine antithrombin II/III (heparin cofactor): a comparison of two methods.
    Br J Haematol. 1975 Oct;31(2):233-43 PMID: 53066
  9. Characterization of human, bovine, and horse antithrombin III.
    Biochemistry. 1976 Jan 27;15(2):368-73 PMID: 1247522
  10. Third component of human complement: purification from plasma and physicochemical characterization.
    Biochemistry. 1976 Oct 5;15(20):4513-21 PMID: 823964
  11. Proteolytic activation of protein C from bovine plasma.
    Biochemistry. 1976 Nov 2;15(22):4893-900 PMID: 990250
  12. Inactivation and binding of human plasma kallikrein by antithrombin III and heparin.
    Thromb Res. 1976 Nov;9(5):457-66 PMID: 1087054
  13. Purification and some properties of factor D of the human properdin system.
    Z Immunitatsforsch Immunobiol. 1976 Nov;152(3):231-43 PMID: 12625
  14. Complement activation by the properdin system: formation of a stoichiometric. C3 cleaving complex of properdin factor B with C36.
    Immunochemistry. 1977 Mar;14(3):201-5 PMID: 863465
  15. Human factor D of the alternative complement pathway: purification and characterization.
    J Immunol. 1977 Jul;119(1):337-42 PMID: 874324
  16. Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis.
    J Biol Chem. 1977 Sep 10;252(17):6097-104 PMID: 408348
  17. Chemical characterization of human factor B of the alternate pathway of complement activation.
    Biochemistry. 1977 Nov 29;16(24):5368-75 PMID: 411505
  18. Actions of urinary kallikrein, plasmin, and other kininogenases on bovine plasma high-molecular-weight kininogen.
    J Biochem. 1978 Jan;83(1):223-35 PMID: 146707
  19. Initiation of the intrinsic coagulation and fibrinolytic pathways of man: the role of surfaces, hageman factor, prekallikrein, high molecular weight kininogen, and factor XI.
    Prog Hemost Thromb. 1978;4:127-75 PMID: 362477
  20. Mechanism of action of factor D of the alternative complement pathway.
    J Exp Med. 1978 Dec 1;148(6):1498-509 PMID: 82604
  21. Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.
    J Immunol. 1979 Jan;122(1):75-81 PMID: 762425
  22. The alternative pathway C3/C5 convertase: chemical basis of factor B activation.
    J Immunol. 1979 Aug;123(2):529-34 PMID: 458145
  23. Isolation and characterization of bovine plasma prekallikrein (Fletcher factor).
    Biochemistry. 1979 Dec 11;18(25):5743-50 PMID: 518867
  24. Partial amino acid sequence of human factor D:homology with serine proteases.
    Proc Natl Acad Sci U S A. 1980 Feb;77(2):1116-9 PMID: 6987665
  25. Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate.
    Biochemistry. 1980 Mar 18;19(6):1151-60 PMID: 6768384
  26. Activation of bovine factor XII (Hageman factor) by plasma kallikrein.
    Biochemistry. 1980 Apr 1;19(7):1322-30 PMID: 6155941
  27. Structural evidence that complement factor B constitutes a novel class of serine protease.
    J Biol Chem. 1980 Sep 25;255(18):8472-6 PMID: 6997298
  28. Molecular biology and chemistry of the alternative pathway of complement.
    Adv Immunol. 1980;29:1-53 PMID: 6158260
  29. Partial sequence of human complement component factor B: novel type of serine protease.
    Proc Natl Acad Sci U S A. 1980 Aug;77(8):4923-7 PMID: 6776529
  30. Active site amino acid sequence of human factor D.
    Proc Natl Acad Sci U S A. 1980 Aug;77(8):4938-42 PMID: 6776531
  31. The proteolytic activation systems of complement.
    Annu Rev Biochem. 1981;50:433-64 PMID: 7023363
  32. Human plasma kallikrein. A rapid purification method with high yield.
    Biochem J. 1981 Jan 1;193(1):187-92 PMID: 6914195
  33. The separation of functionally distinct forms of the third component of human complement (C3).
    Biochem J. 1981 Mar 1;193(3):963-70 PMID: 6458280
  34. The binding of human complement proteins C5, factor B, beta 1H and properdin to complement fragment C3b on zymosan.
    Biochem J. 1981 Dec 1;199(3):485-96 PMID: 6462133
  35. Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site.
    Biochem J. 1980 Jun 1;187(3):863-74 PMID: 6821372
  36. MOLECULAR EXCLUSION AND RESTRICTED DIFFUSION PROCESSES IN MOLECULAR-SIEVE CHROMATOGRAPHY.
    Biochemistry. 1964 May;3:723-30 PMID: 14193644
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1982-03-00
Pages
587-95
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1555245
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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